Country: Australia
Bahasa: Inggeris
Sumber: Department of Health (Therapeutic Goods Administration)
Cisatracurium besylate
1 CISATRACURIUM-AFT INJECTION CISATRACURIUM BESYLATE WHAT IS IN THIS LEAFLET This leaflet answers some common questions about CISATRACURIUM-AFT. It does not contain all of the available information. Reading this leaflet does not take the place of talking to your doctor or pharmacist. Taking any medicine involves some risk. It is possible that all risks associated with this medicine might not have been detected, despite proper testing. Only your doctor or pharmacist is able to weigh up all of the relevant facts, and you should consult them if you have any queries. IF YOU HAVE ANY CONCERNS ABOUT THE USE OF CISATRACURIUM-AFT ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS INFORMATION. You may want to read it again. This leaflet provides information about CISATRACURIUM-AFT. This information should not be applied to any other medicine, even those that are similar or appear to contain the same ingredients. WHAT CISATRACURIUM-AFT IS USED FOR CISATRACURIUM-AFT is used to relax the body's muscles. CISATRACURIUM-AFT will normally be given to you when you are in surgery, or during other medical procedures. CISATRACURIUM-AFT is only used in conjunction with an anaesthetic, so you will be asleep during the procedure. IF YOU HAVE ANY QUESTIONS ABOUT WHY CISATRACURIUM-AFT IS USED ASK YOUR DOCTOR. _HOW DOES CISATRACURIUM-AFT WORK? _ Cisatracurium besylate (the active ingredient in CISATRACURIUM-AFT) belongs to a group of medicines called "neuromuscular blockers". CISATRACURIUM-AFT works by blocking the effects of one of the body's chemical messengers called acetylcholine. Acetylcholine is involved in muscle contraction. By relaxing your bo Baca dokumen lengkap
1 PRODUCT INFORMATION CISATRACURIUM-AFT AFT PHARMACEUTICALS PTY LTD NAME OF THE DRUG Cisatracurium-AFT contains Cisatracurium besylate The chemical name of cisatracurium besylate is (1R,1’R,2R,2’R,)-2,2’-(3,11-dioxo-4,10- dioxatridecamethylene) bis (1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1- veratrylisoquinolinium) dibenzenesulfonate. The molecular formula of cisatracurium besylate is C 65 H 82 N 2 O 18 S 2 and it has a molecular weight of 1243.5. The structural formula is given below: CAS Number: 96946-42-8 DESCRIPTION Cisatracurium besylate is a white to yellowish powder. Cisatracurium-AFT is supplied in two strengths, either 2 mg or 5 mg (as the besylate salt) of cisatracurium besylate per mL. Cisatracurium-AFT also contains Water for Injections and benzenesulfonic acid. Cisatracurium-AFT does not contain any antimicrobial preservative and is intended for single patient use on one occasion only. Discard any residue. PHARMACOLOGY _PHARMACODYNAMICS _ Cisatracurium besylate, a stereoisomer of atracurium, is an intermediate duration, non- depolarising benzylisoquinolinium skeletal muscle relaxant. Cisatracurium besylate binds to cholinergic receptors on the motor end-plate to antagonise the action of acetylcholine, resulting in a competitive block of neuromuscular transmission. This action is readily reversed by anticholinesterase agents such as neostigmine. 2 The ED 95 (dose required to produce 95% depression of the twitch response of the adductor pollicis muscle to stimulation of the ulnar nerve) of cisatracurium besylate is estimated to be 0.05 mg/kg bodyweight during opioid anaesthesia (thiopentone, Baca dokumen lengkap