Country: Amerika Syarikat
Bahasa: Inggeris
Sumber: NLM (National Library of Medicine)
CHLORTHALIDONE (UNII: Q0MQD1073Q) (CHLORTHALIDONE - UNII:Q0MQD1073Q)
Bryant Ranch Prepack
ORAL
PRESCRIPTION DRUG
Diuretics such as chlorthalidone are indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Chlorthalidone has also been found useful in edema due to various forms of renal dysfunction, such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia. Edema during pregnancy may arise from pathologic causes or from the physiologic and mechanical consequences of pregnancy. Chlorthalidone is indicated in pregnancy when edema is due to
Chlorthalidone Tablets, USP are available containing 50 mg of Chlorthalidone, USP. 50 mg Tablets are Light green colour, round tablet, debossed with "N" and score line on one side and plain on other side. 50 mg Tablets are supplied as follows: Bottles of 100 tablets .... NDC 63629-9298-1 Store at 20° to 25°C (68° to 77°F). [See USP for Controlled Room Temperature.]
Abbreviated New Drug Application
CHLORTHALIDONE - CHLORTHALIDONE TABLET BRYANT RANCH PREPACK ---------- TABLETS DESCRIPTION Chlorthalidone is an oral antihypertensive/diuretic. It is a monosulfamyl diuretic that differs chemically from thiazide diuretics in that a double-ring system is incorporated in its structure. It is 2-chloro-5(1-hydroxy-3-oxo-1- isoindolinyl) benzenesulfonamide with the following structural formula: Chlorthalidone, USP is practically insoluble in water, in ether, and in chloroform; soluble in methanol; slightly soluble in ethanol. Chlorthalidone tablets are available containing either 25 mg or 50 mg of chlorthalidone USP and the following inactive ingredients: microcrystalline cellulose, partially pregelatinized maize starch, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate, ingredients of pigment blend yellow like iron oxide yellow, lactose monohydrate, Ferrosoferric Oxide for 25 mg and ingredients of lake blend green like D & C Yellow #10 aluminum lake, FD & C blue #1/ Brilliant Blue FCF Aluminum Lake for 50 mg. CLINICAL PHARMACOLOGY Chlorthalidone is an oral diuretic with prolonged action (48–72 hours) and low toxicity. The major portion of the drug is excreted unchanged by the kidneys. The diuretic effect of the drug occurs in approximately 2.6 hours and continues for up to 72 hours. The mean half-life following a 50 to 200 mg dose is 40 hours. In the first order of absorption, the elimination half-life is 53 hours following a 50 mg dose, and 60 hours following a 100 mg dose. Approximately 75 percent of the drug is bound to plasma proteins, 58 percent of the drug being bound to albumin. This is caused by an increased affinity of the drug to erythrocyte carbonic anhydrase. Nonrenal routes of elimination have yet to be clarified. Data are not available regarding percentage of dose as unchanged drug and metabolites, concentration of the drug in body fluids, degree of uptake by a particular ® organ or in the fetus, or passage across the blood-brain barrier. The drug produces copious diuresis with g Baca dokumen lengkap