Country: Australia
Bahasa: Inggeris
Sumber: Department of Health (Therapeutic Goods Administration)
pravastatin sodium
Apotex Pty Ltd
pravastatin sodium
CHEMMART PRAVASTATIN 1 CHEMMART PRAVASTATIN _Contains the active ingredient pravastatin (as pravastatin sodium) _ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055 _ WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some common questions about pravastatin. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine may be available. ASK YOUR DOCTOR OR PHARMACIST: if there is anything you do not understand in this leaflet, if you are worried about taking your medicine, or to obtain the most up-to-date information You can also download the most up to date leaflet from www.apotex.com.au. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with your medicine. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is Chemmart. It contains the active ingredient pravastatin (as pravastatin sodium). It is used to treat: people who have high blood cholesterol levels (in combination with changes in diet) people who have had a heart attack (including people whose blood cholesterol levels are normal) people who have had an episode of unstable angina. In these people, pravastatin can reduce the risk of having a stroke, further heart disease, or needing a bypass operation. It is also used to treat children and adolescent patients aged 8 years and older who have heterozygous familial hypercholesterolaemia (an inherited disorder which produces high blood cholesterol levels). This is in combination with diet and lifestyle changes. Ask your doctor if you have any questions about why this medicine has been Baca dokumen lengkap
Product Information – Australia Chemmart Pravastatin tablets Page 1 CHEMMART PRAVASTATIN NAME OF THE MEDICINE Pravastatin sodium. Chemical Name: sodium (3R,5R)-7-[(1S,2S,6S,8S,8aR)-1,26,7,8,8a-hexahydro-6-hydroxy-2-methyl-8- [(S)-2-methylbutyryloxy-1-naphthyl]]-3,5-dihydroxyheptanoic acid. Structural Formula: Molecular Formula: C 23 H 35 NaO 7 Molecular Weight: 446.52 CAS Registry Number: 81131-70-6 DESCRIPTION Pravastatin sodium is one of a class of lipid-lowering compounds, the HMG-CoA reductase inhibitors, that reduce cholesterol biosynthesis. These agents are competitive inhibitors of 3-hydroxy-3- methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme catalysing the early rate-limiting step in cholesterol biosynthesis, conversion of HMG-CoA to mevalonate. Pravastatin sodium is an odourless, white to yellowish-white powder or crystalline powder. It is a relatively polar hydrophilic compound with a partition co-efficient (octanol/water) of 0.59 at a pH of 7.0. It is soluble in methanol and water (> 300 mg/mL), slightly soluble in isopropanol and practically insoluble in acetone, chloroform and ether. Each Tablet contains 10mg, 20mg, 40mg or 80mg of Pravastatin sodium, as the active ingredient in addition, each tablet contains the following inactive ingredients: lactose, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, iron oxide red (only in 10 mg tablets), iron oxide yellow (only in 20 mg, 40 mg and 80 mg tablets), brilliant blue FCF (only in 40 mg tablets). PHARMACOLOGY PHARMACOLOGICAL ACTIONS Pravastatin produces its lipid lowering effect in two ways. Firstly, as a consequence of its reversible inhibition of HMG-CoA reductase activity, it affects modest reductions in intracellular pools of cholesterol. This results in an increase in the number of low density lipoprotein (LDL) receptors on cell surfaces and enhanced receptor mediated catabolism and clearance of circulating LDL. Secondly, Product Information – Australia Chemmart Pravastatin tablets Page 2 pravastatin inhibits LDL p Baca dokumen lengkap