Cetrizet D Tablet

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

PSEUDOEPHEDRINE HYDROCHLORIDE; CETIRIZINE HYDROCHLORIDE

Boleh didapati daripada:

PAHANG PHARMACY SDN. BHD.

INN (Nama Antarabangsa):

PSEUDOEPHEDRINE HYDROCHLORIDE; CETIRIZINE HYDROCHLORIDE

Unit dalam pakej:

100Tablet Tablets

Dikeluarkan oleh:

Sun Pharmaceutical Industries Limited

Risalah maklumat

_Consumer Medication Information Leaflet (RiMUP) _
CETRIZET D TABLET
Cetirizine hydrochloride/Pseudoephedrine hydrochloride (5mg/120mg)
1
WHAT IS IN THIS LEAFLET
1.
What
_Cetrizet D_
is used for
2.
How
_Cetrizet D_
works
3.
Before you use
_Cetrizet D_
4.
How to use
_Cetrizet D_
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of
_Cetrizet D_
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT _CETRIZET D_ IS USED FOR
_Cetrizet D_
should be administered when
both
the
antiallergic
properties
of
cetirizine HCl and the nasal decongestant
activity
of
pseudoephedrine
HCl
are
desired.
_Cetrizet D_
is used in the treatment of
symptoms
associated
with
seasonal
allergy
or
hay
fever,
perennial
(throughout
the
year)
allergic
rhinitis
(inflammation of the mucous membrane
inside the nose) and common cold e.g.,
nasal
congestion,
sneezing,
rhinorrhea
(runny nose), nasal and ocular pruritus
(itchy eyes).
HOW _CETRIZET D_ WORKS
Cetirizine is an antihistamine that helps
to
reduce
allergic
symptoms
by
preventing
the
effects
of
a
substance
called histamine, which is produced in
the body during an allergic reaction.
Pseudoephedrine is a decongestant what
works by reducing swelling of the blood
vessels inside your nose. This helps to
open
up
your
nasal
airway,
making
breathing easier.
BEFORE YOU USE _CETRIZET D_
_ _
_When you must not use it _
Do not use Cetrizet D if you have any of
the following:

A history of hypersensitivity to any of
the constituents, to ephedrine or to any
piperazines.

Previous intolerance to
pseudoephedrine.

Breast Feeding

Have
severe
high
blood
pressure
or
severe coronary artery disease (heart
disease).

Taking
or
have
taken
monoamine
oxidase
inhibitors
(for
depression)
within the preceding two weeks. The
concomitant
use
of
pseudoephedrine
and
this
type
of
product
may
occasionally
cause
a
rise
in
blood
pressure.

Kidney
insufficiency,
uncontrolled
hyperthyroidism
(overactive
thyroid),
severe
arrhythmia
(abnormal
heart
rhythm), in

Ciri produk

165 mm
Front side
Size: 165x200 mm
COMPOSITION:
Each film coated tablet of CETRIZET D contains:
Cetirizine Hydrochloride BP 5 mg
Pseudoephedrine Hydrochloride BP 120 mg
(As extended release)
PRODUCT DESCRIPTION:
A yellow coloured, circular, film coated tablet with break line marked
on one side and plain
on the other side.
DESCRIPTION:
Combination of antihistamine and decongestant used to relieve allergic
rhinitis.
ACTION AND MODE OR MECHANISMS OF ACTION:
PHARMACODYNAMIC:
Cetirizine
is
a
potent
antihistamine
with
a
low
potential
for
drowsiness
at
pharmacologically active doses and with additional anti-allergic
properties. It is selective
H -antagonist with negligible effects on other receptors and so is
virtually free from anti-
1
cholinergic and anti-serotonin effects. At pharmacologically active
doses, it induces
neither sedation nor behaviour changes. This may be explained by the
fact that cetirizine
does not cross the blood-brain barrier.
It was shown in human pharmacology studies that cetirizine inhibits
certain effects
produced by exogenous histamine. This activity appears rapidly.
Cetirizine also inhibits
the effects produced by endogenous histamine released in vivo by any
agent. It also
inhibits the cutaneous reaction induced by VIP (Vasoactive Intestinal
Polypeptide) and
substance P, neuropeptides, which are believed to take part in the
allergic reaction.
Cetirizine inhibits the histamine-mediated 'early' phase of the
allergic reaction and also
reduces the migration of inflammatory cells and the release of
mediators associated with
the 'late' allergic response.
Cetirizine markedly reduces bronchial hyper-reactivity to histamine in
the asthmatic
patient. It also reduces the allergic reaction induced by specific
allergens. These effects
are obtained without any central effects being demonstrated either by
psychometric tests
or by quantified EEG.
Pseudoephedrine has direct and indirect sympathomimetic activity and
is an orally
effective upper respiratory tract decongestant. Pseudoephedrine is
substantially l