AZAMUN 50MG TABLETS

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

AZATHIOPRINE

Boleh didapati daripada:

SCHMIDT BIOMEDTECH SDN BHD

INN (Nama Antarabangsa):

AZATHIOPRINE

Unit dalam pakej:

100Tablet Tablets

Dikeluarkan oleh:

DOUGLAS MANUFACTURING LTD

Risalah maklumat

AZAMUN TABLETS
Azathioprine (50mg)
1
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
WHAT IS IN THIS LEAFLET
1.
What
AZAMUN TABLETS
is used for
2.
How
AZAMUN TABLETS
works
3.
Before you use
AZAMUN TABLETS
4.
How to take
AZAMUN TABLETS
5.
While
you
are
using
AZAMUN
TABLETS
6.
Side effects
7.
Storage and Disposal of
AZAMUN
TABLETS
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT AZAMUN TABLETS IS USED FOR
AZAMUN TABLET
is used to treat patients
who have received an organ transplant to
help prevent their body from rejecting
the transplanted organs (e.g. a heart or
kidney).
AZAMUN TABLET
is also used to
suppress the body's immunity to treat
"autoimmune" conditions like
rheumatoid arthritis, and SLE (systemic
lupus erythematosus).
AZAMUN TABLETS
may also be used to
treat other conditions as determined by
your doctor.
HOW AZAMUN TABLETS WORKS
AZAMUN TABLETS
contain the active
ingredient Azathioprine. It belongs to a
group of medicines called
immunosuppressants which work by
reducing the body's own natural
immunity
BEFORE YOU USE AZAMUN TABLETS
-
_When you must not use it _
Do not use
AZAMUN TABLETS
:
_ _

If you are female and you are
pregnant or there is a chance that
you may become pregnant;
Azathioprine is not recommended
during pregnancy. It may cause
birth defects if using it at the time
of conception. Your partner should
take adequate contraceptive
precautions while you are taking
AZAMUN TABLETS
. If you are using
IUD contraceptives it is
recommended that additional
methods of contraception are
employed.

If you are breastfeeding or are
planning to breastfeed.

If you have ever had an allergy to
AZAMUN TABLETS
or any of its
ingredients (listed at the end of this
leaflet), or to another
immunosuppressant medicine (eg.
6-mercaptopurine).
Symptoms of an allergic reaction
may be mild or severe. Signs if you
are suffering an allergic reaction
usually include some of the
following: wheezing, swelling of
the lips / mouth, difficulty in
breathing, hayfever, lumpy

Ciri produk

PRESENTATION
Azathioprine in:
50mg Tablet: Pale yellow, film-coated biconvex tablet; one
side is marked “AZA” and a score over “50”.
USES
_ACTIONS_
Azathioprine is an imidazolyl derivative of mercaptopurine.
It acts as an immunosuppressant and anti-neoplastic agent
with similar actions to those of mercaptopurine, to which
it is converted in the body. Its effects may not be seen for
several weeks after administration.
The exact mechanism of its immunosuppressive action is
not clear. However many of its effects are believed to be
attributable to competitive inhibition of hypoxanthine -
guanine phosphoribosyltransferase by thioinosic acid, the
product of transformation. This competition inhibits nucleic
acid and protein synthesis.
In addition, methylated derivatives of 6-mercaptopurine
may potentiate the suppressive effects of other
6-mercaptopurine derivatives.
Comparative studies utilising 6-mercaptopurine and
azathioprine suggest that 6-mercaptopurine is responsible
for most of the immunosuppressive effects of azathioprine.
Azathioprine suppresses T-cell more than B-cell activity;
it has limited anti-inflammatory properties. Clinically, the
number of mononuclear and granulocytic cells available
for migration to an area of inflammation is decreased.
It also inhibits the proliferation of promyelocytes within
bone marrow, thus decreasing the number of circulating
monocytes available to become macrophages in the
peripheral blood.
Azathioprine exerts its maximum immunosuppressive
effect when given immediately after immunologic
challenge (induction phase). When given prior to
antigen challenge (preinduction phase), it may augment
antibody response in specific immunoglobulin classes.
Azathioprine is not effective when given in the effector
phase (proliferation and maturation phases). Therefore, the
compound has no effect on established graft rejections or
secondary responses.
Azathioprine has been used extensively in
allotransplantation procedures; it also has been
administered in systemic lupus erythematosus, r