Avogra 50mg Tablets

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

SILDENAFIL CITRATE

Boleh didapati daripada:

Abio Marketing Sdn Bhd

INN (Nama Antarabangsa):

SILDENAFIL CITRATE

Unit dalam pakej:

4tablet Tablets

Dikeluarkan oleh:

NANG KUANG PHARM CO

Risalah maklumat

Page 1 of 2 pages
_Consumer Medication Information Leaflet (RiMUP) _
AVOGRA 50MG TABLET
Sildenafil citrate 70.25mg, equivalent to Sildenafil 50mg
WHAT IS IN THIS LEAFLET:_ _
a)
What Avogra is used for
b)
How Avogra works
c)
Before you use Avogra
d)
How to use Avogra
e)
While you are using Avogra
f)
Side effects
g)
Storage and disposal of Avogra
h)
Product description
i)
Manufacturer
j)
Product Registration Holder
k)
Date of revision
WHAT AVOGRA IS USED FOR:
The name of your medicine is Avogra
50mg Tablet (called ‘Avogra’ in this
leaflet).
Avogra is a treatment for men with
erectile dysfunction, sometimes known
as impotence. This is when a man
cannot get, or keep a hard, erect penis
suitable for sexual activity.
You should not take Avogra if you do
not have erectile dysfunction. You
should not take Avogra if you are a
woman.
HOW AVOGRA WORKS:
Avogra contains the active substance
sildenafil which belongs to a group of
medicines called phosphordiesterase
type 5 (PDE 5) inhibitors.
It works by helping to relax the blood
vessels in your penis, allowing blood
to flow into your penis when you get
sexually excited. Avogra will only
help you to get an erection if you are
sexually stimulated.
BEFORE YOU USE AVOGRA
WHEN YOU MUST NOT USE IT:
Do not take this medicine and tell your
doctor if:

If you are taking medicines
containing nitrates, or nitric oxide
donors such as amyl nitrites. These
medicines are often given for relief
of chest pain (angina pectoris).
Avogra can cause a serious increase
in the effects of these medicines.
Tell your doctor if you are taking
any of these medicines. If you are
not certain, ask your doctor or
pharmacist.

If you are allergic (hypersensitive)
to sildenafil or any of the other
ingredients of Avogra.

If you have a severe heart or liver
problem.

If you have recently had a stroke or
a heart attack, or if you have low
blood pressure.

If you have certain eye problems
(such as sensitivity to light and low
vision).

If you have ever had loss of vision
because of certain a

Ciri produk

COMPOSITION:
Each tablet contains:
Sildenafil citrate 70.25 mg
equivalent to 50mg of Sildenafil
PRODUCT DESCRIPTION:
Avogra 50mg Tablet is a white, oval-shaped film coated tablet,
engraved
“NK” in one side and double “526” on the other side.
PHARMACOLOGICAL PROPERTIES:
PHARMACODYNAMIc PROPERTIES
ATC code : G04B E03
Sildenafil is a selective inhibitor of phosphodiesterases (PDEs), with
the
greatest selectivity for PDE type 5. At least 10 isoenzyme families of
PDE
have been identified, several of which (e.g. PDE types 5 and 6)
selectively
hydrolyze cyclic guanosine monophosphate (cGMP) relative to cyclic
adenosine monophosphate (cAMP).
Sildenafil selectively inhibits cGMP-specific PDE type 5, the
principal
isoenzyme involved in the metabolism of cGMP to GMP in the corpora
cavernosa of the penis and clitoris, PDE types 2 and 3 also are
present in
these corpora cavernosa, and sildenafil also inhibits these isoenzymes
albeit substantially less potently (i.e., requires doses exceeding
usual
therapeutic levels). PDE type 5 also has been isolated from lung,
platelets,
kidney, spleen and various vascular (e.g., penile and clitoral corpora
cavernosa) and visceral smooth muscle (e.g., gastric fundus,
esophageal
sphincter, colon) and skeletal muscle but not from cardiac muscle. By
inhibiting PDEtype 5, sildenafil causes accumulation of cGMP in
various
tissues, including the penile and clitoral corpora cavernosa. The role
of
cGMP as a modulator of cAMP signal transduction pathways remains to be
more fully elucidated, but ex vivo studies indicate that sildenafil
does not
appear to appreciably affect cAMP tissue concentrations.
Sildenafil also exhibits some activity against other PDE isoenzymes.
In
vitro, sildenafil is about 10 times more active against PDE type 5
than
against PDE type 6, greater than 70-80 times more active against PDE
type
5 than against PDE type 1, greater than 1000 times more active against
PDE type 5 than against PDE types 2 and 4, and 4000 times more active
against PDE type 5 than against PDE type