Avadol-Fast Tablet 500mg

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Paracetamol

Boleh didapati daripada:

AV MANUFACTURING SDN.BHD

INN (Nama Antarabangsa):

Paracetamol

Unit dalam pakej:

3 x 10 Tablets; 20 x 10 Tablets; 1 x 10 Tablets

Dikeluarkan oleh:

AV MANUFACTURING SDN.BHD

Risalah maklumat

Consumer Medication Information Leaflet (RiMUP)
AVADOL-FAST TABLET 500MG
Paracetamol 500 mg
1
WHAT IS IN THIS LEAFLET
1.
What is Avadol-Fast used for
2.
How Avadol-Fast works
3.
Before you take Avadol-Fast
4.
How to use Avadol-Fast
5.
While you are using Avadol-Fast
6.
Side effects
7.
Storage and disposal
8.
Product description
9.
Manufacturer & Product
registration holder
10.
Date of revision
1.
WHAT IS AVADOL-FAST USED FOR
Avadol-Fast helps to relieve fever,
mild to moderate pain including:
headache, migraine, backache,
musculoskeletal pain, myalgia,
dysmenorrhea (period pain), pain of
osteoarthritis, toothache, and the
discomfort from colds, influenza and
sore throats.
2.
HOW AVADOL-FAST WORKS
Avadol-Fast is rapidly absorbed through
oral administration, and the absorption
takes place mainly in the small intestine.
The excretion of paracetamol is rapid
and occurs via the urine.
3.
BEFORE YOU USE AVADOL-FAST
_-When you must not use it_
If you have ever had

hypersensitivity to paracetamol or any
of the other ingredients/ components
of the product.

taking other medicines containing
paracetamol.

Severe and active hepatic impairment.
_-Before you start to use it_
Check with your doctor, if you

suffer from liver or kidney
problems, including alcoholic liver
disease

suffer from mild arthritis and need
to take painkillers every day

are with impaired kidney or liver
function.
_-Taking another medicines_
Please talk to your doctor or pharmacist,
if you are taking these medicines:

if you are taking blood thinning drugs
(anticoagulants e.g. warfarin) and you
need to take a pain reliever on a daily
basis

If you have recently taken any other
medicines, including medicines
obtained without prescription.
_-Pregnancy and breast-feeding_
Use in pregnancy:

Considered to be the analgesic of
choice in pregnant patients.

Although it crosses placenta,
paracetamol is considered to be safe in
normal therapeutic doses for short-
term use as a minor
analgesic/antipyretic in pregnancy.
Use in Lactat

Ciri produk

AVADOL®-FAST TABLET 500MG ( Paracetamol 500mg)
PRODUCT DESCRIPTION: AVADOL®-FAST TABLET is a white to off-white,
round tablet with logo “500” on one side and plain on the other
side.
PHARMACODYNAMICS: Paracetamol is a centrally acting analgesic and
antipyretic with minimal anti-inflammatory properties.
Analgesic: The mechanism of analgesic action has not been fully
determined. Paracetamol may act predominantly by inhibiting
prostaglandin synthesis in the central nervous system
(specifically cyclooxygenase (COX)-2) and, to a lesser extent, through
a peripheral action by blocking pain- impulse generation.
The peripheral action may also be due to inhibition of prostaglandin
synthesis or to inhibition of the synthesis or actions of other
substances that sensitize pain receptors to
mechanical or chemical stimulation
Antipyretic: Paracetamol
act centrally
on
the
hypothalamic
heat-regulating
center to
produce
peripheral vasodilatation resulting in increased blood flow through
the skin,
sweating and heat loss. Paracetamol reduces fever by inhibiting the
formulation and release of prostaglandins in the CNS and by inhibiting
endogenous pyrogens at the hypothalamic
thermoregulator center.
PHARMACOKINETICS: Following oral administration paracetamol is rapidly
absorbed. Paracetamol absorption takes place mainly in the small
intestine and therefore the rate of
absorption
is
depending on
the
rate of gastric
emptying.
It
has been
shown
that
drugs
which delay gastric emptying also delay the absorption of paracetamol
whereas
metoclopramide (a drug which increases the rate of gastric emptying)
accelerates absorption of the analgesic though the total amount
absorbed does not increase.
The presence of food in the stomach has also been reported to reduce
the rate of absorption of paracetamol. Alterations in gastric pH have
no appreciable effect on paracetamol
absorption. During absorption, the amount of paracetamol which is
inactivated is negligible and it has been shown
that
paracetamol
does
not
affect
gastric
mucosal
permeabil