APO INDAPAMIDE 2.5MG TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

INDAPAMIDE

Boleh didapati daripada:

PHARMAFORTE (MALAYSIA) SDN. BHD.

INN (Nama Antarabangsa):

INDAPAMIDE

Unit dalam pakej:

30 Tablets

Dikeluarkan oleh:

APOTEX INC

Ciri produk

APO-INDAPAMIDE TABLETS
INDAPAMIDE USP 2.5MG
DIURETIC / ANTIHYPERTENSIVE
PHARMACOLOGY: Indapamide is a diuretic antihypertensive agent. The
mechanism whereby
indapamide exerts its action in the control of hypertension is not
completely elucidated: both renal and
extra renal actions may be involved. The renal site of action is the
proximal part of the distal tubule and
the ascending part of Henle's loop. Sodium and chloride ions are
excreted in approximately equivalent
amounts. The increased delivery of sodium to the distal tubular
exchange site results in increased
potassium excretion and hypokalemia.
Indapamide is rapidly and completely absorbed after oral
administration. Peak blood levels are
obtained after 1 to 2 hours. Indapamide is concentrated in the
erythrocytes and is 79% bound to plasma
proteins and to erythrocytes.
It is taken up by the vascular wall in smooth vascular muscle
according to its high lipid solubility.
Seventy per cent of a single oral dose is eliminated by the kidneys
and 23 per cent by the
gastrointestinal tract. Indapamide is metabolized to a marked degree,
the unchanged product
representing approximately 5 per cent of the total dose found in the
urine during the 48 hours following
administration. Elimination of indapamide from the plasma is biphasic
with half-lives of 14 and 25 hours
respectively.
INDICATIONS: APO-INDAPAMIDE (indapamide) is indicated in the
management of essential
hypertension. It may be tried as a sole therapeutic agent in the
treatment of mild to moderate
hypertension. Normally APO-INDAPAMIDE, as other diuretics, is used as
the initial agent in multiple
drug regimens.
CONTRAINDICATIONS: Anuria, progressive and severe oliguria, hepatic
coma, hepatic
impairment and cerebrovascular complications. Known hypersensitivity
to indapamide or to other
sulphonamide derivatives.
PRECAUTIONS AND WARNINGS: Electrolyte changes observed with indapamide
become severe
at doses above 2.5mg per day. Therefore the maximum daily dose should
not exceed this dose.
Patients with renal insuffic