APO-ATENOL 100MG TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ATENOLOL

Boleh didapati daripada:

PHARMAFORTE (MALAYSIA) SDN. BHD.

INN (Nama Antarabangsa):

ATENOLOL

Unit dalam pakej:

30Tablet Tablets; 500Tablet Tablets; 100Tablet Tablets

Dikeluarkan oleh:

APOTEX INC

Risalah maklumat

APO-ATENOL TABLET
Atenolol (50mg, 100mg)
1
_Consumer Medication Information Leaflet (RiMUP)_
WHAT IS IN THIS LEAFLET
1.
What Apo-Atenol is used for
2.
How Apo-Atenol works
3.
Before you use Apo-Atenol
4.
How to use Apo-Atenol
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Apo-Atenol
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
WHAT APO-ATENOL
IS USED FOR
Apo-Atenol can be used for:
•
high blood pressure
•
symptoms of chest pain (angina)
HOW APO-ATENOL WORKS
Apo-Atenol belongs to a class of drugs
called beta-blockers. Atenolol acts by
blocking the action of certain chemicals
(hormones) on the heart and the blood
vessels and affects, amongst other things,
the heart rate and the heart’s workload.
BEFORE YOU USE APO-ATENOL
-
_When you must not use it _
Do not use this product if you have
any known heart failure/
complications/ problems, as this
product might cause greater stress to
your heart. This includes sinus
bradycardia (decreased heart rate
pattern), atrioventricular block/ AV
block (impairment of conduction
between the chambers in the heart). If
you are unsure, always talk to your
health consultant before taking this
product.
You must not use this product if you
are allergic to atenolol or any other
ingredient in this product.
_ _
_ _
_Pregnancy and lactation _
Do not take Apo-Atenol if you are
pregnant, trying to get pregnant or think
you may be pregnant.
Do not take Apo-Atenol if you are
breast-feeding. Ask your doctor or
pharmacist for advice before taking any
medicine.
_ _
-
_Before you start to use it _
Before you start using this medication,
you should inform your doctor if you
have:
- any other type of medical condition
you have, such as thyrotoxicosis
(excess of thyroid hormones in the
body, diabetes, kidney function
problem, or any heart related disease.
-any planned surgeries in the near
future, or had just undergone a
surgery, whether minor or major.
-
_Taking other medicines _
It is not advised to take a combination
of more

Ciri produk

APO-ATENOL
ATENOLOL TABLETS 50MG AND 100MG
ANTIHYPERTENSIVE AND ANTI-ANGINAL AGENT
ACTIONS
: Apo-Atenol (atenolol) is a beta-adrenergic receptor blocking agent
with predominant effect on beta
1
receptors. It does not possess membrane stabilizing or intrinsic
sympathomimetic (partial agonist) activities. The
mechanism of the antihypertensive effect has not been established.
Among the factors that may be involved are
a) competitive ability to antagonize catecholamine-induced tachycardia
at the beta-receptor sites in the heart
thus decreasing cardiac output; b) inhibition of renin release by the
kidneys; c) inhibition of the vasomotor
centres. The mechanism of the anti-anginal effect is also uncertain.
An important factor may be the reduction of
myocardial oxygen requirements by blocking catecholamine-induced
increases in heart rate, systolic blood
pressure and the velocity and extent of myocardial contraction.
PHARMACOKINETICS:
Approximately 50% of an oral dose of atenolol is absorbed from the
gastrointestinal tract
and the remainder being excreted unchanged in the feces. 6% to 16% of
atenolol is bound to plasma protein.
Maximum plasma concentrations are reached within 2-4 hours. The mean
peak plasma concentrations of
atenolol
were
approximately
300
and
700
nanogram/mL
following
administration
of
50
and
100mg
respectively.
The
plasma
half-life
is
approximately
6-7
hours.
Atenolol
is
extensively
distributed
to
extravascular tissues but only a small amount is found in the central
nervous system. Approximately 10% of
atenolol is metabolized in man. About 3% of the material recovered in
the urine was the hydroxylated
metabolite which has been shown in animal studies to have 10% of the
pharmacological activity of atenolol.
Approximately 47 and 53% of the oral dose is eliminated in the urine
and feces respectively. Recovery is
complete after 72 hours. A comparative bioavailability study was
performed using normal human volunteers.
The rate and extent of absorption after a single oral 100mg dose of
Tenormin 100mg or Apo-A