Apo-Atenidone Tablets 10025 mg

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ATENOLOL; CHLORTHALIDONE

Boleh didapati daripada:

PHARMAFORTE (MALAYSIA) SDN. BHD.

INN (Nama Antarabangsa):

ATENOLOL; CHLORTHALIDONE

Unit dalam pakej:

30Tablet Tablets

Dikeluarkan oleh:

APOTEX INC

Risalah maklumat

_Consumer Medication Information Leaflet (RiMUP) _
1
APO-ATENIDONE TABLETS
Atenolol (100mg)/ Chlorthalidone (25mg)
WHAT IS IN THIS LEAFLET
1.
What Apo-Atenidone is used
for
2.
How Apo-Atenidone works
3.
Before you use Apo-
Atenidone
4.
How to use Apo-Atenidone
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Apo-
Atenidone
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
WHAT APO-ATENIDONE IS USED FOR
This is a combination product that
contains 2 medications: atenolol
and chlorthalidone. It is used to
treat high blood pressure.
HOW APO-ATENIDONE WORKS
Atenolol belongs to the class of
medications called beta-blockers.
It works by decreasing the
workload of the heart.
Chlorthalidone belongs to the
class of medications called
diuretics (water pills). It works by
getting rid of excess salt and
water.
BEFORE YOU USE APO-ATENIDONE
_- When you must not use it_
_ _
Do not use this medication if you:
•
are allergic to atenolol,
chlorthalidone or any
ingredients of the medication
•
have a condition called
cardiogenic shock (occurs
when the heart is unable to
pump as much blood as the
body needs)
•
have a condition known as
pheochromocytoma (a type of
tumour that may cause
hypertension) which has not
been treated.
•
have a condition known as
right ventricular failure (a
heart condition) caused by
pulmonary hypertension
(abnormally high blood
pressure in the arteries of the
lungs)
•
have a severely slow heart
rate
•
have a serious heart block,
also called atrioventricular
(AV) block
•
have metabolic acidosis (a
condition where your body
produces too much acid)
•
have severe peripheral
arterial disorders (blockage of
blood flow to limbs of body)
•
have sick sinus syndrome
•
have uncontrolled congestive
heart failure
•
have very low blood pressure
_- Before you start to use it_
_ _
Tell your doctor if:
•
You have any other medical
conditions that require
attention
•
You have hyperuricemia (an
excess of uric acid in the
blood)
•
You have

Ciri produk

APO-ATENIDONE TABLETS 100/25 MG
ATENOLOL 100MG AND CHLORTHALIDONE 25 MG
ANTIHYPERTENSIVE AGENT
PRODUCT DESCRIPTION
White, round biconvex tablets. Engraved 100 over
European bisect 25 on one side, and engraved APO on
the other.
PHARMACOLOGY
APO-ATENIDONE
(atenolol/chlorthalidone)
combines the antihypertensive activity of two agents, a
beta adrenergic receptor blocking agent (atenolol) and
a diuretic (chlorthalidone).
Atenolol is a beta
1
-selective, beta adrenergic blocking
agent,
devoid
of
membrane
stabilizing
or
intrinsic
sympathomimetic (partial agonist) activities. It is a
racemic mixture and the beta
1
properties reside in the
S(-)
enantiomer.
Beta
1
-selectivity
decreases
with
increasing dose.
The
mechanism
of
the
antihypertensive
effect
of
atenolol has not been established. Among the factors
that may be involved are:
a)
competitive
ability
to
antagonize
catecholamine-induced
tachycardia
at
the
beta
receptor
sites
in
the
heart,
thus
decreasing cardiac output.
b)
Inhibition of renin release by the kidneys.
c)
Inhibition of the vasomotor centres.
Chlorthalidone, a monosulfonamyl diuretic, increases
excretion
of
sodium
and
chloride.
Natriuresis
is
accompanied
by
some
loss
of
potassium.
The
mechanism
by which
chlorthalidone
reduces blood
pressure is not fully known by may be related to the
exrection
and
redistribution
of
body
sodium.
Chlorthalidone
usually
does
not
decrease
normal
blood pressure.
The
combination
of
atenolol
with
thiazide-like
diuretics
has
been
shown
to
be
compatible
and
generally more effective than either drug used alone as
an antihypertensive agent.
Pharmacokinetics: Approximately 40 to 50% of an
oral
dose
of
atenolol
is
absorbed
from
the
gastrointestinal
tract,
the
remainder
being
excreted
unchanged in the feces. Peak plasma concentrations
occur 2-4 hours after dosing and are subject to a 4-fold
variability. The plasma levels are proportional to dose
over the range 50-400 mg and 6 to 16% of atenolol is
bound
to
plasma
proteins.
The
plasma
half-life
is
approximately 6-7 hours.
Approximately 6