APO-AMITRIPTYLINE 10MG TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

AMITRIPTYLLINE HYDROCHLORIDE

Boleh didapati daripada:

PHARMAFORTE (MALAYSIA) SDN. BHD.

INN (Nama Antarabangsa):

AMITRIPTYLLINE HYDROCHLORIDE

Unit dalam pakej:

500 Tablets

Dikeluarkan oleh:

APOTEX INC

Ciri produk

APO-AMITRIPTYLINE
AMITRIPTYLINE HCL TABLETS USP 10MG AND 25MG
ANTIDEPRESSANT
PHARMACOLOGY:
Amitriptyline is structurally and pharmacologically related to
imipramine, desipramine and
nortriptyline. In experimental animals, amitriptyline exhibits a
disruptive action on the electroencephalogram and
on operant behavior, a fairly strong anticonvulsant action, a
peripheral atropine like action, antihistamine and
antiserotonin effects, some adrenergic blockage, and a gastric
antisecretory effect. Amitriptyline is not a MAO
inhibitor. The manner in which it exerts its clinical antidepressant
effect is uncertain. Amitriptyline is well
absorbed from gastrointestinal tract. Antidepressant effects may not
be apparent for 2 or more weeks. It is
metabolized by the liver to active (nortriptyline) and inactive
metabolites. Elimination half-life is 10 to 50 hours.
Amitriptyline
is
excreted
in
the
urine
and
bile
as
conjugates
of
the
cis
and
trans
isomers
of
10-
hydroxynortriptyline.
INDICATIONS:
The treatment of depression including that accompanied by anxiety.
Amitriptyline has been found
effective in reducing the incidence of enuresis in some cases where
organic pathology has been excluded.
CONTRAINDICATIONS:
Known
hypersensitivity.
Concomitant
administration
with
MAO
inhibitors
has
been
considered an absolute contraindication; however, patients with
refractory depression have received combination
therapy without significant adverse effects. If used in combination
therapy, give the drugs orally, avoid large doses
and monitor the patient closely. Not recommended during the acute
recovery phase following myocardial
infarction and in the presence of acute congestive heart failure.
PRECAUTIONS:
Amitriptyline should be used with caution in patients with a history
of seizures or urinary retention,
or with narrow angle glaucoma or increased intraocular pressure.
Arrhythmias, sinus tachycardia and prolongation
of the conduction time have been reported, particularly with high
doses. A few instances of unexpected death have
been reported