APO-ACYCLOVIR 800MG

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ACYCLOVIR

Boleh didapati daripada:

PHARMAFORTE (MALAYSIA) SDN. BHD.

INN (Nama Antarabangsa):

ACYCLOVIR

Unit dalam pakej:

100Tablet Tablets; 35 Tablet Tablets

Dikeluarkan oleh:

APOTEX INC

Risalah maklumat

APO-ACYCLOVIR TABLET
Acyclovir (200mg, 400mg, 800mg)
1
_Consumer Medication Information Leaflet (RiMUP)_
WHAT IS IN THIS LEAFLET
1.
What Apo-Acyclovir is used for
2.
How Apo-Acyclovir works
3.
Before you use Apo-Acyclovir
4.
How to use Apo-Acyclovir
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Apo-
Acyclovir
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
WHAT APO-ACYCLOVIR
IS USED FOR
Apo-Acyclovir is indicated for the
treatment of herpes genitalis (a common
sexually transmitted infection marked by
genital pain and sore) and herpes zoster
(shingles)
HOW APO-ACYCLOVIR WORKS
Apo-Acyclovir is a prescription
medication containing the active
ingredient, acyclovir.
Apo-Acyclovir is
an antiviral medicine. It slows the growth
and spread of the herpes virus so that the
body can fight off the infection.
BEFORE YOU USE APO-ACYCLOVIR
-
_When you must not use it_
Do not use this product if you are
allergic to
_ _
acyclovir, or any ingredients
in this medication (refer to
PRODUCT
DESCRIPTION
)
_Pregnancy and lactation_
Do not take Apo-Acyclovir if you are
pregnant, trying to get pregnant or
think you may be pregnant.
Do not take Apo-Acyclovir if you are
breast-feeding. Ask your doctor or
pharmacist for advice before taking
any medicine.
-
_Before you start to use it_
Before you start to use Apo-Acyclovir,
your doctor needs to know any
medical condition that you may have,
including kidney and liver disease.
Inform your doctor if you are pregnant
or plan to pregnant before taking Apo-
Acyclovir. Your doctor will discuss
the risk and benefit of taking it with
you.
-
_Taking other medicines_
Tell your doctor if you are taking any
other medicines, including any that
you buy without a prescription from a
pharmacy, supermarket or health food
shop.
Example of medicines that might
interact with Apo-Acyclovir when
taken together is probenacid, a
medicine used to treat high uric acid.
Consult your doctor or pharmacist if
you are not sure, as they will have a
more comple

Ciri produk

APO‐ACYCLOVIR 800MG TABLETS
Acyclovir Tablets
ANTIVIRAL AGENT
PHARMACOLOGY : Acyclovir, a synthetic acyclic purine nucleoside
analog, is a substrate with a high degree of
specificity for herpes simplex and varicella‐zoster specified
thymidine kinase. Acyclovir is a poor substrate for
host cell‐specified thymidine kinase. Herpes simplex and
varicella‐
zoster specified thymidine kinase transform
acyclovir to its monophosphate which is then transformed by a number
of cellular enzymes to acyclovir
diphosphate and acyclovir triphosphate. Acyclovir triphosphate is both
an inhibitor of, and a substrate for,
herpesvirus‐specified DNA polymerase. Although the cellular
α
‐DNA polymerase in infected cells may also be
inhibited by acyclovir triphosphate, this occurs only at
concentrations of acyclovir triphosphate which are higher
than those which inhibit the herpesvirus‐specified DNA polymerase.
Acyclovir is selectively converted to its active
form in herpesvirus‐infected cells and is thus preferentially taken
up by these cells. Acyclovir has demonstrated a
very much lower toxic potential in _ vitro_ for normal uninfected
cells because : 1) less is taken up; 2) less is
converted to the active form; 3) cellular
α
‐DNA polymerase has a lower sensitivity to the action of the active
form of the drug. A combination of the thymidine kinase specificity,
inhibition of DNA polymerase and premature
termination of DNA synthesis results in inhibition of herpesvirus
replication. No effect on latent non‐replicating
virus has been demonstrated. Inhibition of the virus reduces the
period of viral shedding, limits the degree of
spread and level of pathology, and thereby facilitates healing. During
suppression there is no evidence that
acyclovir prevents neural migration of the virus. It aborts episodes
of recurrent herpes due to inhibition of viral
replication following reactivation.
The pharmacokinetics of acyclovir after oral administration have been
evaluated in 6 clinical studies involving 110
adult patients. In on