Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ACYCLOVIR
PHARMAFORTE (MALAYSIA) SDN. BHD.
ACYCLOVIR
100 Tablets; 25 Tablets
APOTEX INC
APO-ACYCLOVIR TABLET Acyclovir (200mg, 400mg, 800mg) 1 _Consumer Medication Information Leaflet (RiMUP)_ WHAT IS IN THIS LEAFLET 1. What Apo-Acyclovir is used for 2. How Apo-Acyclovir works 3. Before you use Apo-Acyclovir 4. How to use Apo-Acyclovir 5. While you are using it 6. Side effects 7. Storage and Disposal of Apo- Acyclovir 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT APO-ACYCLOVIR IS USED FOR Apo-Acyclovir is indicated for the treatment of herpes genitalis (a common sexually transmitted infection marked by genital pain and sore) and herpes zoster (shingles) HOW APO-ACYCLOVIR WORKS Apo-Acyclovir is a prescription medication containing the active ingredient, acyclovir. Apo-Acyclovir is an antiviral medicine. It slows the growth and spread of the herpes virus so that the body can fight off the infection. BEFORE YOU USE APO-ACYCLOVIR - _When you must not use it_ Do not use this product if you are allergic to _ _ acyclovir, or any ingredients in this medication (refer to PRODUCT DESCRIPTION ) _Pregnancy and lactation_ Do not take Apo-Acyclovir if you are pregnant, trying to get pregnant or think you may be pregnant. Do not take Apo-Acyclovir if you are breast-feeding. Ask your doctor or pharmacist for advice before taking any medicine. - _Before you start to use it_ Before you start to use Apo-Acyclovir, your doctor needs to know any medical condition that you may have, including kidney and liver disease. Inform your doctor if you are pregnant or plan to pregnant before taking Apo- Acyclovir. Your doctor will discuss the risk and benefit of taking it with you. - _Taking other medicines_ Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop. Example of medicines that might interact with Apo-Acyclovir when taken together is probenacid, a medicine used to treat high uric acid. Consult your doctor or pharmacist if you are not sure, as they will have a more comple Baca dokumen lengkap
APO‐ACYCLOVIR 400MG TABLETS Acyclovir Tablets ANTIVIRAL AGENT PHARMACOLOGY : Acyclovir, a synthetic acyclic purine nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella‐zoster specified thymidine kinase. Acyclovir is a poor substrate for host cell‐specified thymidine kinase. Herpes simplex and varicella‐ zoster specified thymidine kinase transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate and acyclovir triphosphate. Acyclovir triphosphate is both an inhibitor of, and a substrate for, herpesvirus‐specified DNA polymerase. Although the cellular α ‐DNA polymerase in infected cells may also be inhibited by acyclovir triphosphate, this occurs only at concentrations of acyclovir triphosphate which are higher than those which inhibit the herpesvirus‐specified DNA polymerase. Acyclovir is selectively converted to its active form in herpesvirus‐infected cells and is thus preferentially taken up by these cells. Acyclovir has demonstrated a very much lower toxic potential in _ vitro_ for normal uninfected cells because : 1) less is taken up; 2) less is converted to the active form; 3) cellular α ‐DNA polymerase has a lower sensitivity to the action of the active form of the drug. A combination of the thymidine kinase specificity, inhibition of DNA polymerase and premature termination of DNA synthesis results in inhibition of herpesvirus replication. No effect on latent non‐replicating virus has been demonstrated. Inhibition of the virus reduces the period of viral shedding, limits the degree of spread and level of pathology, and thereby facilitates healing. During suppression there is no evidence that acyclovir prevents neural migration of the virus. It aborts episodes of recurrent herpes due to inhibition of viral replication following reactivation. The pharmacokinetics of acyclovir after oral administration have been evaluated in 6 clinical studies involving 110 adult patients. In on Baca dokumen lengkap