ANPRODROXIL GRANULES FOR ORAL SUSPENSION 125mg5ml

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

CEFADROXYL

Boleh didapati daripada:

MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.

INN (Nama Antarabangsa):

CEFADROXYL

Unit dalam pakej:

60ml mL

Dikeluarkan oleh:

MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
1
ANPRODROXIL
GRANULES
FOR
ORAL
SUSPENSION 125MG/5ML
Cefadroxil (125mg/5ml)
WHAT IS IN THIS LEAFLET
1.
What Anprodroxil Granules for
Oral Suspension 125mg/5ml is
used for
2.
How Anprodroxil Granules for
Oral
Suspension
125mg/5ml
works
3.
Before
you
use
Anprodroxil
Granules
for
Oral
Suspension
125mg/5ml
4.
How
to
use
Anprodroxil
Granules
for
Oral
Suspension
125mg/5ml
5.
While you are using it
6.
Side effects
7.
Storage
and
Disposal
of
Anprodroxil Granules for Oral
Suspension 125mg/5ml
8.
Product description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of Revision
WHAT
ANPRODROXIL
GRANULES
FOR
ORAL
SUSPENSION
125MG/5ML
IS
USED FOR
Cefadroxil
is
the
active
ingredient
for Anprodroxil Granules
for Oral
Suspension 125mg/5ml.
Cefadroxil can be used to treat

Throat infections

Urinary tract infection

Infection in the skin
HOW
ANPRODROXIL
GRANULES
FOR
ORAL SUSPENSION 125MG/5ML WORKS
Cefadroxil is an antibiotic. It belongs
to
a
group
of
antibiotics
that
are
called cephalosporin. These types of
antibiotics are similar to penicillin.
Cefadroxil kills bacteria and it can
be
used
against
various
sorts
of
infections.
BEFORE
YOU
USE
ANPRODROXIL
GRANULES
FOR
ORAL
SUSPENSION
125MG/5ML
-
_When you must not use it _

If
you
have
known
hypersensitivity
to
penicillin
or
with
known
histories allergy to any of
the
cephalosporins
or
any
of its ingredient.

If you have acute porphyria
(include
forms
of
the
disease that typically affect
nervous system).
-
_Before you start to use it _
You must tell your doctor if:

You have allergies to any
medicine
which
you
have
taken
previously
to
treat
your current condition.

You are pregnant, trying to
become
pregnant
as
the
safety
has
not
been
established.

You are breast feeding as
small
quantities
are
found
in milk of nursing mothers.

You experienced severe or
immediate
hypersensitivity
reactions
to
a
penicillin.
There may be an increased
risk of you being allergic to
Anprodroxil
Granules
for
Oral
Suspensi

Ciri produk

7105-03
ANPRODROXIL GRANULES FOR ORAL SUSPENSION 125MG/5ML
NAME AND STRENGTH OF ACTIVE SUBSTANCE:
Each 5ml of reconstituted suspension contains Cefadroxil (base) 125mg
PRODUCT DESCRIPTION:
Red granules with raspberry & strawberry flavour and sweet taste.
When reconstituted with water, the product is converted into palatable
suspension for oral administration.
PHARMACODYNAMICS
:
Cefadroxil belongs to the first generation cephalosporins. It is broad
spectrum in activity. It is active _ in vitro_ against many Gram-
positive aerobic cocci but has limited activity against Gram-negative
bacteria. The beta-lactam ring of the structure is the chemical
group associated
with antibacterial activity. The final reaction in bacterial cell-wall
synthesis is a cross-linking of adjacent
peptidoglycan strands by transpeptidation reaction. This reaction
involves cleavage of the terminal alanine from the penta-peptide
attached to N-acetylglucosamine. A pentapeptide bridge is then added
between the remaining D-alanine on one linear peptide and L-
lysine on another linear peptide, thus completing the cross-linking of
the adjacent peptidoglycan polymers. The cephalosporins are
structurally similar to the terminal D-alanyl-D-alanine portion and,
therefore can compete for and bind to proteins (enzymes) that
catalyse
transpeptidation
and
cross-linking.
These
proteins
are
called
penicillin-binding
proteins
(PBPs)
and
consists
of
transpeptidases, transglycosylases and D-alanine carboxykinases. The
transpeptidases have different function in the cells, and
selective inactivation of each transpeptidases results in different
effect on the bacterial cells. Interference with the PBPs responsible
for the cross-linking of the peptidoglycan polymers results in the
formation of a structurally weakened cell wall and, ultimately, cell
death.
PHARMACOKINETICS:
Cefadroxil is acid-stable and rapidly and almost completely absorbed
from the gastro-intestinal tract. The rate of absorption and peak
plasma concentrations are not affected when administered with