Aetos Metformin MR Tablet 850mg

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

METFORMIN HYDROCHLORIDE

Boleh didapati daripada:

Hovid Pharmacy Sdn. Bhd.

INN (Nama Antarabangsa):

METFORMIN HYDROCHLORIDE

Unit dalam pakej:

100Tablet Tablets; 60 Tablet Tablets

Dikeluarkan oleh:

HOVID BERHAD

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
HP METFORMIN MR TABLET 850MG
METFORMIN (850MG)
1
WHAT IS IN THIS LEAFLET?
1.
What
HP
Metformin
MR
850
mg tablet is used for
2.
How HP Metformin MR 850 mg
tablet works
3.
Before
you
use
HP
Metformin MR 850 mg tablet
4.
How to take HP Metformin MR
850 mg tablet
5.
While
you
are
using
HP
Metformin MR 850 mg tablet
6.
Side effects
7.
After using HP Metformin MR
850 mg tablet
8.
Product description
9.
Manufacturer
10.
Product Registration Holder
11.
Date of revision
WHAT HP METFORMIN MR 850 MG
TABLET IS USED FOR
Used to treat type 2 diabetes or non-
insulin
dependent
diabetes
mellitus
(NIDDM) in adults whose high blood
sugar
levels
cannot
be
lowered
through
exercising
or
monitoring
food intake.
HOW HP METFORMIN MR 850 MG
TABLET WORKS
This
medicine
belongs
to
a
group
called
biguanides
that
lowers
the
high blood sugar levels in the body.
It works by:

reducing
the
amount
of
blood
sugar produced in the liver

improving your body’s sensitivity
towards insulin and the way the
body uses insulin

slowing down the rate of glucose
being absorbed in the intestines.
BEFORE YOU USE HP METFORMIN MR
850 MG TABLET
_When you must not take it _
Do not take this medicine if:

you are allergic to meformin, any
other biguanide, or its excipients

you
have
diabetic
coma
(when
your
blood
sugar
is
abnormally
high
and
body
is
severely
dehydrated)

you
have
severe
burns
and infections

you have kidney problems

you have liver problems

you
have
undergone/are
undergoing major surgery

you have severe trauma

you have an active or history of
lactic acidosis (buildup of acid in
the
blood
due
to
inefficient
removal from the body)

you
have
severe
breathing
difficulties

you have heart or blood vessel
problems eg. heart failure, heart
attack, sudden/rapid development
of blood failing to circulate in the
body

you are breastfeeding or plan to
breastfeed

you
are
pregnant
or
plan
to
become pregnant.
_Before you start to take it _
Tell your doctor if:
�

Ciri produk

DESCRIPTION
Round, white uncoated tablet with convex faces.
COMPOSITION
Metformin
Hydrochloride
850
mg
per
tablet
(Extended-Release)
PHARMACODYNAMICS
Metformin is an oral biguanide antidiabetic agent. Its
mode of action is thought to be multifactorial and
includes
delayed
uptake
of
glucose
from
the
gastro-intestinal tract; increased peripheral glucose
utilization mediated by increased insulin sensitivity;
and
inhibition
of
increased
hepatic
and
renal
gluconeogenesis.
PHARMACOKINETICS
Metformin Hydrochloride is slowly and incompletely
absorbed
from
the
gastrointestinal
tract.
The
absolute bioavailability of a single 500mg dose is
reported to be about 50 to 60%, although this is
reduced
somewhat
if
taken
with
food.
Plasma
protein
binding
is
negligible.
It
is
excreted
unchanged in the urine. The plasma elimination
half-life is reported to range from about 2 to 6 hours
after oral administration.
INDICATIONS
Metformin
is
used
in
the
treatment
of
non-insulin-dependent diabetes mellitus (type 2) in
adults,
not
responding
to
exercise
and
dietary
modification.
Diabetmin
may
be
used
as
monotherapy
or
in
combination
with
other
oral
antidiabetic agents, or with insulin.
CONTRAINDICATIONS
This medication is contraindicated in patients with
the following medical problems:
•
Hypersensitivity to metformin.
•
Any
condition
needing
close
blood
glucose
control,
such
as:
severe
burns,
dehydration,
diabetic
coma,
diabetic
ketoacidosis,
hyperosmolar nonketotic coma, severe infection,
major surgery, and severe trauma.
•
Conditions associated with hypoxemia, such
as:
cardiorespiratory
insufficiency,
cardiovascular collapse, congestive heart failure,
acute myocardial infarction.
•
Severe, acute, or chronic hepatic disease.
•
Active or history of lactic acidosis.
•
Renal function impairment or renal disease.
•
Diagnostic
or
medical
examinations
using
intravascular iodinated contrast media such as:
angiography,
intravenous
cholangiography,
computed tomography (CT) scan, pyelography
and urography.
•
Severely reduced kidney f