Acetan Tablet 50mg

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

LOSARTAN POTASSIUM

Boleh didapati daripada:

Duopharma Marketing Sdn. Bhd.

INN (Nama Antarabangsa):

LOSARTAN POTASSIUM

Unit dalam pakej:

30tablet Tablets

Dikeluarkan oleh:

DUOPHARMA MANUFACTURING (BANGI) SDN BHD

Risalah maklumat

_Consumer Medication Information Leaflet (RiMUP) _
1
ACETAN TABLET
_LOSARTAN POTASSIUM _
_ _
WHAT IS IN THIS LEAFLET
1.
WHAT ACETAN IS USED FOR
2.
HOW ACETAN WORKS
3.
BEFORE YOU USE ACETAN
4.
HOW TO USE ACETAN
5.
WHILE YOU ARE USING IT
6.
SIDE EFFECTS
7.
STORAGE AND DISPOSAL OF ACETAN
8.
PRODUCT DESCRIPTION
9.
MANUFACTURER AND PRODUCT
REGISTRATION HOLDER
10.
DATE OF REVISION
This
leaflet
answers
some
common
questions
about
Acetan.
It
does
not
contain all the available information. It
does not take the place of talking to
your pharmacist or doctor.
All medicines have risks and benefits.
Your pharmacist or doctor has weighed
the risks of you taking Acetan against
the benefits they expect it will have for
you. If you have any concerns about
taking
this
medicine,
ask
your
pharmacist or doctor.
Keep this leaflet with the medicine.
You may need to read it again.
1.
WHAT ACETAN IS USED FOR
It is used to:
•
Treat high blood pressure
(hypertension)
•
Reduce
the
risk
of
stroke
in
patients with high blood pressure
and thickening of the left ventricle
(one of two large chambers that
collect and expel blood received in
the heart)
•
Protect
the
kidney
in
diabetic
patients
(Type
2,
Non-insulin
dependent)
with
high
blood
pressure and protein in the urine
2.
HOW ACETAN WORKS
Acetan
belongs
to
a
group
of
medicines,
called
angiotensin-II
receptor antagonists. It works to lower
your blood pressure by relaxing your
blood vessels. In addition, Acetan
slows the progression of kidney disease
in people who have type 2 diabetes
mellitus with protein in the urine.
Acetan is not addictive.
3.
BEFORE YOU USE ACETAN
-
_WHEN YOU MUST NOT USE IT _
Do not take Acetan if:
•
you are pregnant or breast-feeding
•
you have an allergy to Acetan or
any of the ingredients listed at the
end of this leaflet
•
the packaging is torn or shows
signs of tampering
•
the expiry date on the pack has
passed.
Your doctor or pharmacist has more
information on medicines to be careful
with or avoid while taking Acetan.
-
_BEFORE YOU START TO USE IT _
Tel

Ciri produk

I.
DESCRIPTION
ACETAN TABLET 50MG : An ellipse, white film coated tablet plain on one
side and ‘50’ on the
other side. Each tablet contains losartan potassium 50mg.
ACETAN TABLET 100MG : An ellipse, white film coated tablet marked
‘100’ on one side and
scored on other side. Each tablet contains losartan potassium 100mg.
II. CLINICAL PHARMACOLOGY
PHARMACODYNAMIC PROPERTIES
Losartan is an oral angiotensin II receptor (type AT1) antagonist.
Angiotensin II binds to the
AT1 receptor found in many tissues (e.g. vascular smooth muscle,
adrenal gland, kidneys and
the heart) and elicits several important biological actions, including
vasoconstriction and the
release of aldosterone. Angiotensin II also stimulates smooth muscle
cell proliferation. Based
on binding and pharmacological bioassays, losartan binds selectively
to the AT1 receptor.
There is also an AT2 receptor found in many tissues. The functions of
AT2 receptors have not
been established. In vitro and in vivo, both losartan and its
pharmacologically active carboxylic
acid metabolite (E-3174) block all physiologically relevant actions of
angiotensin II, regardless
of the source or route of synthesis. The active metabolite is 10 to 40
times more potent by
weight than losartan and appears to be a reversible, non-competitive
inhibitor of the AT1
receptor.
During losartan administration, removal of angiotensin II negative
feedback on renin secretion
leads to increased plasma renin activity. Increases in plasma renin
activity lead to increases
in
angiotensin
II
in
plasma.
Even
with
these
increases,
antihypertensive
activity
and
suppression
of
plasma
aldosterone
concentration
are
maintained,
indicating
effective
angiotensin II receptor blockade.
Losartan binds selectively to the AT1 receptor and does not bind to or
block other hormone
receptors or ion channels important in cardiovascular regulation.
Furthermore, losartan does
not inhibit ACE (kininase II), the enzyme that degrades bradykinin.
Consequently, effects not
directly related to blocking the AT1 recept