Valsts: Amerikas Savienotās Valstis
Valoda: angļu
Klimata pārmaiņas: NLM (National Library of Medicine)
VERAPAMIL HYDROCHLORIDE (UNII: V3888OEY5R) (VERAPAMIL - UNII:CJ0O37KU29)
State of Florida DOH Central Pharmacy
VERAPAMIL HYDROCHLORIDE
VERAPAMIL HYDROCHLORIDE 240 mg
ORAL
PRESCRIPTION DRUG
Verapamil HCl Extended-Release Tablets are indicated for the management of essential hypertension. Verapamil Hydrochloride Extended-Release Tablets are contraindicated in: - Severe left ventricular dysfunction (see WARNINGS ). - Hypotension (systolic pressure less than 90 mm Hg) or cardiogenic shock. - Sick sinus syndrome (except in patients with a functioning artificial ventricular pacemaker). - Second- or third-degree AV block (except in patients with a functioning artificial ventricular pacemaker). - Patients with atrial flutter or atrial fibrillation and an accessory bypass tract (e.g., Wolff-Parkinson-White, Lown-Ganong-Levine syndromes) (see WARNINGS ). - Patients with known hypersensitivity to verapamil hydrochloride.
Verapamil Hydrochloride are supplied by State of Florida DOH Central Pharmacy as follows: Store between 20˚ to 25˚ C (68˚ to 77˚ F) [See USP Controlled Room Temperature]. PROTECT FROM LIGHT AND MOISTURE Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required). KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN. You may report side effects to FDA at 1-800-FDA-1088 Ranbaxy PRINCETON, NJ This Product was Repackaged By: State of Florida DOH Central Pharmacy 104-2 Hamilton Park Drive Tallahassee, FL 32304 United States
New Drug Application
VERAPAMIL HYDROCHLORIDE - VERAPAMIL HYDROCHLORIDE TABLET, FILM COATED, EXTENDED RELEASE STATE OF FLORIDA DOH CENTRAL PHARMACY ---------- VERAPAMIL HCL EXTENDED-RELEASE TABLETS USP RX ONLY DESCRIPTION Verapamil hydrochloride is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist). The tablets are designed for extended-release of the drug in the gastrointestinal tract; extended-release characteristics are not altered when the tablet is divided in half. Verapamil hydrochloride is not chemically related to other cardioactive drugs. Verapamil hydrochloride is chemically designated as Benzeneacetonitrile, α-[3-[[2-(3,4- dimethoxyphenyl)ethyl]-methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-monohydrochloride and has the following structural formula: C H N O ●HCl M.W. 491.07 Verapamil hydrochloride is a white or practically white crystalline powder, practically odorless with a bitter taste. It is soluble in water, methanol, and chloroform. Each extended-release tablet, for oral administration, contains 240 mg, 180 mg or 120 mg verapamil hydrochloride. In addition to verapamil hydrochloride the tablets contain the following inactive ingredients: sodium alginate, microcrystalline cellulose, povidone, magnesium stearate. The coating for verapamil 240 mg tablets contains: hydroxypropyl cellulose, hypromellose, titanium dioxide, polyethylene glycol, D&C Yellow No. 10 Aluminum lake. The coating for verapamil 180 mg tablets contains: hypromellose, titanium dioxide, polyethylene glycol, FD & C Yellow No. 6 Aluminum lake, polysorbate 80. The coating for verapamil 120 mg tablets contains: hypromellose, titanium dioxide, polyethylene glycol, polydextrose powder, triacetin, synthetic yellow iron oxide. All three strengths: 120 mg, 180 mg, and 240 mg meet USP Drug Release Test #2. CLINICAL PHARMACOLOGY Verapamil HCl is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell membran Izlasiet visu dokumentu