Valsts: Kanāda
Valoda: angļu
Klimata pārmaiņas: Health Canada
VANCOMYCIN (VANCOMYCIN HYDROCHLORIDE)
STERIMAX INC
J01XA01
VANCOMYCIN
1G
POWDER FOR SOLUTION
VANCOMYCIN (VANCOMYCIN HYDROCHLORIDE) 1G
INTRAVENOUS
20ML
Prescription
GLYCOPEPTIDES
Active ingredient group (AIG) number: 0131315009; AHFS:
APPROVED
2018-01-10
_Product Monograph – _ _Pr_ _Vancomycin Hydrochloride for Injection USP _ _Page 1 of 31_ PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION INFORMATION PR VANCOMYCIN HYDROCHLORIDE FOR INJECTION USP 500 MG/VIAL, 1 G/VIAL, 5 G/VIAL AND 10 G/VIAL VANCOMYCIN STERILE LYOPHILIZED POWDER FOR SOLUTION Antibiotic SteriMax Inc. 2770 Portland Drive Oakville, Ontario L6H 6R4 CONTROL NO.: 220151 DATE OF REVISION: November 5, 2018 _Product Monograph – _ _Pr_ _Vancomycin Hydrochloride for Injection USP _ _Page 2 of 31_ PRODUCT MONOGRAPH PR VANCOMYCIN HYDROCHLORIDE FOR INJECTION USP 500 MG/VIAL, 1 G/VIAL, 5 G/VIAL AND 10 G/VIAL VANCOMYCIN STERILE LYOPHILIZED POWDER FOR SOLUTION THERAPEUTIC CLASSIFICATION Antibiotic ACTIONS AND CLINICAL PHARMACOLOGY The bactericidal action of vancomycin against most gram-positive bacteria results from the inhibition of the biosynthesis of peptidoglycan polymers during the second stage of cell wall synthesis in dividing organisms. This effect occurs at a site different from that of penicillins and cephalosporins. The cytoplasmic membrane composition may also be affected and membrane permeability altered. There is also evidence that vancomycin selectively inhibits RNA synthesis. Vancomycin is a tricyclic glycopeptide antibiotic derived from _Amycolatopsis _ _orientalis_ (formerly _Nocardia orientalis_ ). It is primarily active against gram-positive organisms including staphylococci and streptococci. It is active against methicillin-resistant strains of _Staphylococcus _ _aureus_ and _Staphylococcus epidermidis. _ Vancomycin is poorly absorbed from the gastrointestinal tract. It is given intravenously for therapy of systemic infections. Following intravenous administration, vancomycin is widely distributed and inhibitory concentrations of vancomycin can be documented in the pericardial, pleural, ascitic, and synovial fluids. Low concentrations of the drug may appear in CSF if meninges are inflamed. The volume of distribution for vancomycin ranges from 0.43 to 1.25 L/kg. At a concentration of 10 to 1 Izlasiet visu dokumentu