Valsts: Austrālija
Valoda: angļu
Klimata pārmaiņas: Department of Health (Therapeutic Goods Administration)
Allopurinol
Arrow Pharma Pty Ltd
Allopurinol
TERRY WHITE CHEMISTS ALLOPURINOL _contains the active ingredient, allopurinol (al-oe-PUR-in-ol)_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. ASK YOUR DOCTOR OR PHARMACIST IF YOU DO NOT UNDERSTAND ANYTHING OR ARE WORRIED ABOUT TAKING YOUR MEDICINE. This leaflet answers some common questions about allopurinol. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. Some more recent information on your medicine may be available. Speak to your pharmacist or doctor to obtain the most up-to-date information. All medicines have risks and benefits. Your doctor or pharmacist has weighed the risks of you taking this medicine against the benefits they expect it will have for you. KEEP THIS LEAFLET WITH YOUR MEDICINE. You may need to read it again. WHAT ALLOPURINOL IS USED FOR The name of your medicine is Terry White Chemists Allopurinol. It contains the active ingredient, allopurinol. Allopurinol is used to treat: • gouty arthritis or gout • kidney stones • rare conditions where high levels of uric acid occur in the blood (for example, Lesch-Nyhan syndrome). Allopurinol is used to treat the symptoms of these conditions, but it will not cure them. Also, it will not help treat the pain that occurs in an acute attack of gout. _HOW IT WORKS_ Allopurinol belongs to a group of medicines called anti-uricaemic agents. These medicines work by reducing high levels of uric acid in the body, which are usually due to gout. Excess amounts of uric acid in the blood may lead to uric acid crystals being made and deposited in the joints, thereby causing pain, swelling and tenderness. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed allopurinol for another reason. This medicine is available only with a doctor's prescription. There is no evidence th Izlasiet visu dokumentu
1 TERRY WHITE ALLOPURINOL NAME OF THE MEDICINE Allopurinol. Chemical Name: 1,5-dihydro-4H-pyrazolo[3,4-_d_]pyrimidin-4-one. Chemical Structure: Molecular Formula: C 5 H 4 N 4 O Molecular Weight: 136.1 CAS Registry No: 315-30-0 DESCRIPTION Allopurinol is a white or off-white, almost odourless powder. It is very slightly soluble in water and in alcohol, and is practically insoluble in chloroform and in ether. It dissolves in dilute solutions of alkali hydroxides. Terry White Allopurinol also contains the following excipients: lactose monohydrate, magnesium stearate, povidone and maize starch. PHARMACOLOGY Allopurinol inhibits xanthine oxidase, the enzyme which catalyses the conversion of hypoxanthine to xanthine, and of xanthine to urate/uric acid. Allopurinol decreases urate formation in two ways: the inhibition of xanthine oxidase reduces the amount of hypoxanthine and xanthine converted to urate/uric acid; this action makes more hypoxanthine and xanthine available for re-utilisation in the purine metabolic cycle, which in turn, by a feedback mechanism, decreases overall _de novo _purine formation. Since allopurinol decreases urate formation, it reduces urate/uric acid concentrations in both body fluids and urine. In contrast, the uricosuric agents which increase urate/uric acid excretion via the kidney will reduce the urate concentration in body fluids, but increase urate/uric acid concentrations in urine. Reduction of the urate concentrations in body fluids by allopurinol permits mobilisation and dissolution of urate deposits anywhere in the body, the commonest sites being those in the skin, bones, joints and kidney interstitial tissue. Therapeutic effects therefore include: the resolution of skin tophi and the healing of urate sinuses; eventual reduction in the frequency of attacks of acute gouty arthritis; improvement in joint mobility; reduction of the urate load to be excreted via the kidney; prevention and treatment of acute uric acid nephropathy; and, in the long-term, reduced risk of renal impairment by Izlasiet visu dokumentu