Valsts: Izraēla
Valoda: angļu
Klimata pārmaiņas: Ministry of Health
PIPERACILLIN AS SODIUM SALT; TAZOBACTAM AS SODIUM SALT
BIOAVENIR LTD, ISRAEL
J01CG02
POWDER FOR SOLUTION FOR INJECTION
TAZOBACTAM AS SODIUM SALT 500 MG; PIPERACILLIN AS SODIUM SALT 4000 MG
I.V
Required
LABORATORY REIG JOFRE S.A., SPAIN
TAZOBACTAM
TAZOBACTAM
Antibiotic for the treatment of systemic and/or local bacterial infections caused by susceptible organisms.Tazo-Pip Avenir in combination with an aminoglycoside, is indicated for the treatment of suspected bacterial infections in neutropenic adults and children. Appendicitis complicated by rupture with peritonitis and/or abscess formation in children aged 2-12 years.
2016-09-30
_אפורל ןולעב )תוחיטב עדימ ( הרמחה לע העדוה_ _ ןכדועמ(_ _05.2013_ _)_ __________ ךיראת 22.7.14 םושירה רפסמו תילגנאב רישכת םש TAZO-PIP AVENIR 4.5G 146-80-33342-00 __ _____________ םושירה לעב םש BIOAVENIR LTD . _______________________ ! דבלב תורמחהה טורפל דעוימ הז ספוט תושקובמה תורמחהה ןולעב קרפ יחכונ טסקט שדח טסקט POSOLOGY , DOSAGE & ADMINISTER ATION Tazo-Pip Avenir 4.5g may be given by slow intravenous injection (over at least three to five minutes) or by slow intravenous infusion (over 20-30 minutes). For reconstitution instructions, see section 6.6. The treatment of mixed infections caused by piperacillin susceptible organisms and beta-lactamase producing organisms susceptible to piperacillin/tazobactam generally do not require the addition of another antibiotic. In patients with nosocomial pneumonia and infections in neutropenic patients Tazo-Pip Avenir can be used with an aminoglycoside. If the use of an aminoglycoside is needed with piperacillin/tazobactam, both Tazo-Pip Avenir 4.5g and the aminoglycoside must be used in completely therapeutic doses. Neutropenic patients with signs of infection (e.g. fever) should receive immediate empirical antibiotic therapy before laboratory results are available. _ADULTS AND CHILDREN OVER 12 YEARS, EACH WITH NORMAL _ _RENAL FUNCTION _ The usual dosage for adults and children over 12 years is Tazo-Pip Avenir 4.5 g given every eight hours. POSOLOGY The dose and frequency of Tazo-Pip Avenir 4.5g depends on the severity and localisation of the infection and expected pathogens. _Adult and adolescent patients_ _Infections_ The usual dose is 4 g piperacillin / 0.5 g tazobactam given every 8 hours. For nosocomial pneumonia and bacterial infections in neutropenic patients, the recommended dose is 4 g piperacillin / 0.5 g tazobactam administered every 6 hours. This regimen may also be applicable to treat patients with other indicated infec Izlasiet visu dokumentu
1. NAME OF THE MEDICINAL PRODUCT Tazo-Pip Avenir 4.5 g Powder for Solution for Injection or Infusion. 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each vial contains 4 g piperacillin (as sodium salt) and 0.5 g tazobactam (as sodium salt). One vial of powder for solution for injection or infusion contains 9.44 mmol (217 mg) of sodium. Go to top of the page 3. PHARMACEUTICAL FORM Powder for solution for injection or infusion. White to off white powder. Tazo-Pip Avenir 4.5g (Piperacillin/Tazobactam for Injection) is an injectable antibacterial combination product consisting of the semisynthetic antibiotic piperacillin sodium and the beta- lactamase inhibitor tazobactam sodium for intravenous administration. Piperacillin sodium is derived from D( - )-α-aminobenzyl-penicillin. The chemical name of piperacillin sodium is sodium (_2_S,_5_R,_6_R)-6-[(R)-2-(4-ethyl-2,3-dioxo-1- piperazinecarboxamido)-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1- azabicyclo[3.2.0]heptane-2-carboxylate. The chemical formula is C 23 H 26 N 5 Na0 7 S and the molecular weight is 539.5. The chemical structure of piperacillin sodium is: Tazobactam sodium, a derivative of the penicillin nucleus, is a penicillanic acid sulfone. Its chemical name is sodium (2_S_,3_S_,5_R_)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-methyl)-4-thia-1- azabicyclo[3.2.0]heptane-2- carboxylic acid 4,4-dioxide. The chemical formula is C 10 H 11 N 4 Na0 5 S and the molecular weight is 322.3. The chemical structure of tazobactam sodium is: Go to top of the page 4. CLINICAL PARTICULARS Go to top of the page 4.1 Therapeutic indications Antibiotic for the treatment of moderate to severe systemic and/or local bacterial infections caused by susceptible organisms. Piperacillin/Tazobactam in combination with an aminoglycoside, is indicated for the treatment of suspected bacterial infections in neutropenic adults and children. Appendicitis complicated by rupture with peritonitis and/or abscess formation in children aged 2-12 years. This indication of the medicine has not been evaluate Izlasiet visu dokumentu