Quinapril Pfizer

Valsts: Austrālija

Valoda: angļu

Klimata pārmaiņas: Department of Health (Therapeutic Goods Administration)

Aktīvā sastāvdaļa:

Quinapril hydrochloride

Pieejams no:

Pfizer Australia Pty Ltd

Klase:

Medicine Registered

Lietošanas instrukcija

QUINAPRIL PFIZER
®

_Quinapril hydrochloride_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Quinapril Pfizer.
It does not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Quinapril
Pfizer against the benefits they
expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
QUINAPRIL PFIZER TABLETS.
You may need to read it again.
WHAT QUINAPRIL PFIZER
IS USED FOR
Quinapril Pfizer is used to:
•
lower high blood pressure
(hypertension)
•
treat heart failure.
HYPERTENSION
Quinapril Pfizer is used to lower high
blood pressure (hypertension).
Everyone has blood pressure. This
pressure helps get your blood all
around your body. Your blood
pressure may be different at different
times of the day, depending on how
busy or worried you are. You have
hypertension (high blood pressure)
when your blood pressure stays
higher than is needed, even when you
are calm and relaxed.
There are usually no symptoms of
hypertension. The only way of
knowing that you have hypertension
is to have your blood pressure
checked on a regular basis. If high
blood pressure is not treated it can
lead to serious health problems,
including stroke, heart disease and
kidney failure.
HEART FAILURE
Heart failure means that the heart
muscle is weak and cannot pump
blood strongly enough to supply all
the blood needed throughout the
body. Heart failure is not the same as
heart attack and does not mean that
the heart stops. Heart failure may
start off with no symptoms, but as the
condition progresses, patients may
feel short of breath or may get tired
easily after light physical activity
such as walking. Some patients may
wake up short of breath at night.
Fluid may collect in different parts of
the body, often first noticed as
swollen ankles and feet.
_HOW QUINAP

Produkta apraksts

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PRODUCT INFORMATION

QUINAPRIL PFIZER
®
 (QUINAPRIL HYDROCHLORIDE) 
NAME OF THE MEDICINE 
QUINAPRIL PFIZER (quinapril hydrochloride) 5 mg, 10 mg and 20
mg tablets. 
QUINAPRIL  PFIZER  contains  the  active  ingredient  quinapril  hydrochloride.    Quinapril 
hydrochloride  is  the  hydrochloride  salt  of  quinapril,  the  ethyl  ester  of  a  nonsulfhydryl, 
angiotensin-converting  enzyme  (ACE)  inhibitor,  quinaprilat.    Quinapril  is  chemically  and 
pharmacologically related to enalapril. 
The structural formula of quinapril hydrochloride is shown
below: 

Chemical name: 
2-(S)-[N-[[1-ethoxycarbonyl]-3-phenylpropyl]-(S)-alanyl]-1,2,3,4-
tetrahydro-3-(S)-isoquinoline carboxylic acid, monohydrochloride 
Molecular formula: 
C
25
H
30
N
2
O
5.
HCl 
Molecular weight: 
474.98 
CAS Registry Number: 
82586-55-8. 
DESCRIPTION 
Quinapril  hydrochloride  is  a  white  to  off-white  amorphous  powder  that  is  freely  soluble  in 
aqueous solvents.  The drug molecule contains three chiral centres but is present as the pure 
S-S-S-stereoisomer. 
QUINAPRIL  PFIZER  tablets  also  contain  magnesium  carbonate,  lactose,  gelatin, 
crospovidone, magnesium stearate, candelilla wax and Opadry
Y-5-0920. 
PHARMACOLOGY 
PHARMACODYNAMICS 
Quinapril is deesterified to the principal metabolite, quinaprilat, which is an inhibitor of ACE 
activity  in  human  subjects  and  animals.    ACE  is  a  peptidyl  dipeptidase  that  catalyses  the 
conversion of angiotensin I to the vasoconstrictor, angiotensin II.  The effect of quinapril in 
hypertension  appears  to  result  primarily  from  the  inhibition  of  circulating  and  tissue  ACE 

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