Valsts: Dienvidāfrikas Republika
Valoda: angļu
Klimata pārmaiņas: South African Health Products Regulatory Authority (SAHPRA)
Lennon
PAX®-2 TABLET PAX®-5 TABLET PAX®-10 TABLET SCHEDULING STATUS: S5 PROPRIETARY NAME (and dosage form): PAX ® -2 TABLET PAX ® -5 TABLET PAX ® -10 TABLET COMPOSITION: Each tablet contains 2 mg (5 mg, 10 mg) Diazepam . PHARMACOLOGICAL CLASSIFICATION: A 2.6 Tranquillisers. PHARMACOLOGICAL ACTION: It has been found that the major locus of CNS depressant action of diazepam on spinal reflexes is the brain stem reticular system. After oral administration peak plasma concentrations are reached in 1 to four hours. Drug elimination follows a biphasic pattern, with a rapid phase (half-life = 2 to 3 hours) followed by a slow decay with a half-life of 2 to 8 days. Diazepam is metabolized to active products including oxazepam. One third is excreted as oxazepam and 70% of the metabolites appear in the urine. Metabolites have been found in the urine and in the plasma 14 days after a 10 mg dose. Diazepam is extensively bound to plasma proteins (99%). INDICATIONS: Diazepam is used in the treatment of anxiety in neurotic patients and for pre-operative medication. It may be effective in relieving the acute symptoms of the alcohol withdrawal syndrome, but has no specific usefulness in the treatment of psychotic patients. Diazepam is only indicated when the disorder is severe, disabling or subjecting the individual to extreme stress. CONTRA-INDICATIONS: Diazepam is contra-indicated in infants and in patients with known hypersensitivity to diazepam. Pre-existing CNS depression or coma is normally a contra-indication. Caution should be observed when giving diazepam to patients with impaired hepatic or renal function. In elderly and debilitated patients and patients with impaired obstructive airways disease large doses may produce syncope. The effects of diazepam may be enhanced by alcohol, bar Izlasiet visu dokumentu