MUPIROCIN ointment

Valsts: Amerikas Savienotās Valstis

Valoda: angļu

Klimata pārmaiņas: NLM (National Library of Medicine)

Aktīvā sastāvdaļa:

Mupirocin (UNII: D0GX863OA5) (Mupirocin - UNII:D0GX863OA5)

Pieejams no:

Taro Pharmaceuticals U.S.A., Inc.

Ievadīšanas:

TOPICAL

Receptes veids:

PRESCRIPTION

Ārstēšanas norādes:

Mupirocin ointment is indicated for the topical treatment of canine bacterial infections of the skin, including superficial pyoderma, caused by susceptible strains of Staphylococcus aureus and Staphylococcus intermedius . This drug is contraindicated in animals with a history of sensitivity reactions to any of its components.

Produktu pārskats:

Mupirocin ointment is supplied in 5 g, 15 g, 22 g, and 30 g tubes. Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature] Keep Out of Reach of Children

Autorizācija statuss:

Abbreviated New Animal Drug Application

Produkta apraksts

MUPIROCIN- MUPIROCIN OINTMENT
TARO PHARMACEUTICALS U.S.A., INC.
----------
MUPIROCIN
OINTMENT USP, 2%
_For dermatologic use on dogs_
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
Each gram of mupirocin ointment contains 20 mg of mupirocin in a
bland, water-
washable ointment base consisting of polyethylene glycol 400 and
polyethylene glycol
3350 (polyethylene glycol ointment). Mupirocin is a
naturally-occurring, broad-spectrum
antibiotic. The chemical name is
9-4-[5S-(2S,3S-epoxy-5S-hydroxy-4S-methylhexyl)-
3R,4R-dihydroxytetrahydropyran-2S-yl]-3-methylbut-2(E)-enoyloxy-nonanoic
acid. The
chemical structure is:
CLINICAL PHARMACOLOGY
Mupirocin is a chemical entity produced by fermentation of the
organism _Pseudomonas_
_fluorescens_. Mupirocin inhibits bacterial protein synthesis by
reversibly and specifically
binding to bacterial isoleucyl transfer-RNA synthetase. Due to this
mode of action,
mupirocin shows no cross resistance with chloramphenicol,
erythromycin, gentamicin,
lincomycin, neomycin, novobiocin, penicillin, streptomycin, and
tetracycline. Mupirocin is
an antimicrobial agent that inhibits the growth of gram-positive and
gram-negative
bacteria.
Bacteria susceptible to the action of mupirocin _in vitro_ include the
aerobic isolates of
_Staphylococcus aureus_ (including methicillin-resistant strains and
β-lactamase-producing
strains), _Staphylococcus intermedius, Staphylococcus epidermidis_,
other coagulase
positive or negative Staphylococci, α-hemolytic Streptococci, β
group A Streptococci
(including _S. pyogenes)_, other β Streptococci (including _S.
agalactiae)_, group D
Streptococci (including _S. faecalis_ and _S. faecium)_, group
Viridans Streptococci,
_Streptococcus pneumoniae, Corynebacterium hofmanii, Bacillus
subtilis, Escherichia coli,_
_Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris,
Enterobacter cloacae,_
_Enterobacter aerogenes, Citrobacter freundii, Hemophilus influenzae_
(including β-
lactamase-producing strains),