Valsts: Amerikas Savienotās Valstis
Valoda: angļu
Klimata pārmaiņas: NLM (National Library of Medicine)
Diatrizoate Sodium (UNII: V5403H8VG7) (Diatrizoic acid - UNII:5UVC90J1LK)
Amersham Health Inc.
Diatrizoate Sodium
INJECTION, SOLUTION
500 mg in 1 mL
INTRAVENOUS
PRESCRIPTION DRUG
HYPAQUE sodium 50 percent is indicated for excretory urography, cerebral and peripheral angiography, aortography, intraosseous venography, direct cholangiography, hysterosalpingography, splenoportography, and contrast enhancement of computed tomographic head imaging. Diatrizoate salts are used in small, medium, and large dose urography (see Dosage and Administration—EXCRETORY UROGRAPHY). Visualization of the urinary tract can be achieved by either direct intravenous bolus injection, intravenous drip infusion, or incidentally following intra-arterial procedures.Visualization of the urinary tract is delayed in infants less than 1 month old, and in patients with urinary tract obstruction (see CLINICAL PHARMACOLOGY). Injectable radiopaque contrast media may be used to refine diagnostic precision in areas of the brain which may not otherwise have been satisfactorily visualized. Radiopaque diagnostic agents may be useful to investigate the presence and extent of certain malignancies such as: gliomas including malig
Vials of 50 mL, rubber stoppered, box of 25 (NDC 0407-0766-04). Protect from light. Store at 15°C to 30°C (59° F to 86°F).
HYPAQUE SODIUM- DIATRIZOATE SODIUM INJECTION, SOLUTION AMERSHAM HEALTH INC. ---------- HYPAQUE™ SODIUM (DIATRIZOATE SODIUM INJECTION, USP) 50% Sterile Aqueous Injection FOR EXCRETORY UROGRAPHY CEREBRAL ANGIOGRAPHY PERIPHERAL ANGIOGRAPHY AORTOGRAPHY INTRAOSSEOUS VENOGRAPHY DIRECT CHOLANGIOGRAPHY HYS TEROS ALPINGOGRAPHY SPLENOPORTOGRAPHY NOT FOR INTRATHECAL USE RX ONLY DESCRIPTION HYPAQUE sodium, brand of diatrizoate sodium, is a radiopaque diagnostic agent, water-soluble organic iodide contrast medium. In pure form, it contains 59.87 percent organically bound iodine. The 50 percent (w/v) solution contains 300 mg iodine per mL and 0.8 mEq (18.1 mg) sodium per mL. It has an osmolality of 1515 mosm/kg (determined by VPO), and is hypertonic to blood. As a point of information only, a 10 percent solution (w/v) is isotonic. The viscosity (cp) is about 3.25 at 25° C and 2.34 at 37° C. Sodium carbonate and hydrochloric acid have been added to adjust pH between 6.5 and 7.7.The pKa is 3.4 for diatrizoic acid. If a solution of this medium is chilled, crystals may form but readily dissolve if the vial is placed in moderately hot water before use; cool to body temperature before injecting. The sterile aqueous solution is clear and nearly colorless. It is relatively thermostable and may be autoclaved without harmful effects, although it should be protected from strong light. The 50 percent solution contains edetate calcium disodium 1:10,000 as a sequestering stabilizing agent. Diatrizoate sodium is a triiodinated benzoic acid derivative, the sodium salt of 3,5-diacetamido-2,4,6- triiodobenzoate with a molecular weight of 635.90, and has the following structural formula: CLINICAL PHARMACOLOGY Intravascular injection of a radiopaque diagnostic agent opacifies those vessels in the path of the flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. At physiologic pH, the water-soluble contrast media are completely dissociated into a r Izlasiet visu dokumentu