FUROSEMIDE- furosemide tablet

Valsts: Amerikas Savienotās Valstis

Valoda: angļu

Klimata pārmaiņas: NLM (National Library of Medicine)

Aktīvā sastāvdaļa:

FUROSEMIDE (UNII: 7LXU5N7ZO5) (FUROSEMIDE - UNII:7LXU5N7ZO5)

Pieejams no:

Vedco, Inc.

SNN (starptautisko nepatentēto nosaukumu):

FUROSEMIDE

Kompozīcija:

FUROSEMIDE 12.5 mg

Ievadīšanas:

ORAL

Receptes veids:

PRESCRIPTION

Ārstēšanas norādes:

Dogs - Furosemide Tablets are indicated for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute non-inflammatory tissue edema. In cases of edema involving cardiac insufficiency, the continued use of heart stimulants such as digitalis or its glycosides is indicated. The rationale for efficacious use of diuretic therapy is determined by the clinical pathology producing the edema. Animal reproductive studies have shown that furosemide may cause fetal abnormality and the drug is contraindicated in pregnant animals. Furosemide is contraindicated in anuria, furosemide hypersensitivity, hepatic coma, or during electrolytic imbalances. Monitor serum electrolytes, BUN and CO2 frequently. Monitor serum potassium levels and watch for signs of hypocalcemia. Corticosteroids cause an additive potassium-depletion effect.

Produktu pārskats:

Furosemide Tablets are available in 12.5 mg and 50 mg strength and supplied in bottles containing 500 tablets. NDC 50989-389-52 12.5 mg – 500 tablets NDC 50989-269-52 50 mg – 500 tablets

Autorizācija statuss:

New Animal Drug Application

Produkta apraksts

FUROSEMIDE- FUROSEMIDE TABLET
VEDCO, INC.
----------
FUROSEMIDE TABLETS
NADA 129-034, Approved by FDA
Furosemide Tablets are not USP for dissolution.
For use in dogs only.
CAUTION:
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DES CRIPTION:
Furosemide is a potent loop diuretic which is a derivative of
anthranilic acid. The structure is:
Chemical Name: 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid.
Furosemide is pharmacodynamically characterized by the following:
1) It is administered orally. It is easily absorbed from the
intestinal tract and begins to act in 30 to 60
minutes after oral administration.
2) Is a loop diuretic which inhibits reabsorption of sodium and
chloride at the ascending loop of Henle
in the kidneys, enhancing water excretion.
3) A dose-response relationship and a ratio of minimum to maximum
effective dose range greater than
tenfold.
4) A high degree of efficacy, low inherent toxicity and a high
therapeutic index.
ACTIONS :
The therapeutic efficacy of Furosemide Tablets is from the activity of
the intact and unaltered molecule
throughout the nephron, inhibiting the reabsorption of sodium not only
in the proximal and distal tubule
but also in the ascending limb of the loop of Henle. The prompt onset
of action is a result of the drug's
rapid absorption and a poor lipid solubility. The low lipid solubility
and a rapid renal excretion
minimize the possibility of its accumulation in tissues and organs or
crystalluria. Furosemide Tablets
have no inhibitory effect on carbonic anhydrase or aldosterone
activity in the distal tubule. The drug
possesses diuretic activity either in the presence of acidosis or
alkalosis.
INDICATIONS :
Dogs - Furosemide Tablets are indicated for the treatment of edema
(pulmonary congestion, ascites)
1, 2
3
1
1, 2, 4, 5, 6
Dogs - Furosemide Tablets are indicated for the treatment of edema
(pulmonary congestion, ascites)
associated with cardiac insufficiency and acute non-inflammatory
tissue edema. In cases of edema
involving cardiac