Valsts: Malaizija
Valoda: angļu
Klimata pārmaiņas: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ERYTHROMYCIN ETHYLSUCCINATE
KCK PHARMACEUTICAL INDUSTRIES SDN. BHD.
ERYTHROMYCIN ETHYLSUCCINATE
60 ml
KCK PHARMACEUTICAL INDUSTRIES SDN. BHD.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ _ _ ERYTHROMED GRANULES 200 (ERYTHROMYCIN 200MG/5ML GRANULES FOR ORAL SUSPENSION) Erythromycin Ethylsuccinate equivalent to Erythromycin (200mg/5ml) 1 WHAT IS IN THIS LEAFLET 1. What ERYTHROMED is used for 2. How ERYTHROMED works 3. Before you use ERYTHROMED 4. How to use ERYTHROMED 5. While you are using ERYTHROMED 6. Side effects 7. Storage and disposal 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of revision 11. Serial number WHAT ERYTHROMED IS USED FOR ERYTHROMED is indicated in the treatment of infections caused by susceptible organisms in the diseases listed below: upper and lower respiratory tract infections, pertussis (whooping cough), skin and soft tissue infections, otitis media, erythrasma (skin disease), listeriosis (infection due to contaminated food), diphtheria (infection that affects your nose and throat), primary syphilis (sexually transmitted infection) and prophylaxis of infection of the heart. HOW ERYTHROMED WORKS ERYTHROMED contains erythromycin ethylsuccinate, which is an antibiotic (macrolide group). These medicines work by killing or stopping the growth of bacteria, which cause infections. BEFORE YOU USE ERYTHROMED _-When you must not use it _ Do not take ERYTHROMED if you are: allergic to erythromycin or to other antibiotics from the macrolide family. individual with impaired hepatic function. or someone in your family has a history of heart rhythm disorders (ventricular cardiac arrhythmia or torsades de pointes) or an abnormality of the electrocardiogram (electrical recording of the heart) called “long QT syndrome”. suffer from rhabdomyolysis (muscle injury) having hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency. having abnormally low levels of potassium or magnesium in your blood (hypomagnesaemia or hypokalaemia) _-Pregnancy and breastfeeding _ Tell your doctor or pharmacist if you are pregnant, planning to get Izlasiet visu dokumentu
ERYTHROMED GRANULES 200 (ERYTHROMYCIN 200MG/5ML GRANULES FOR ORAL SUSPENSION) COMPOSITION AND STRENGTH OF ACTIVE INGREDIENTS: Each 5ml of reconstituted suspension contains Erythromycin Ethylsuccinate equivalent to Erythromycin 200mg PRODUCT DESCRIPTION An almost white powder when reconstituted forms a white, vanilla flavoured, homogenous suspension. PHARMACODYNAMICS Erythromycin and other macrolides bind reversibly to the 50S subunit of the ribosome, resulting in blockage of the transpeptidation or translocation reactions, inhibition of protein synthesis, and hence inhibition of cell growth. Its action is predominantly bacteriostatic, but high concentrations are slowly bactericidal against the more sensitive strains. Because of the ready penetration of macrolides into white blood cells and macrophages there has been some interest in their potential synergy with host defence mechanism in vivo. Its actions are increased at moderately alkaline pH (up to about 8.5), particularly in Gram-negative species, probably because of the improved cellular penetration of the nonionised form of the drug. Erythromycin has a broad spectrum activity. The pathogenic organisms which are usually sensitive to Erythromycin include: a) Gram-positive cocci: _Streptococcus pneumoniae_ , _Str. pyogenes. Staphylococcus aureus_ . b) Gram-positive organisms: _Bacillus anthracis, Corynebacterium diphtheriae_ etc. c) Gram-negative cocci: _Neisseria meningitidis, N. gonnorrhoeae, Moraxela catarrhalis_ . d) Gram-negative organisms: _Bordetella _ spp _., Pasteurella, Haeemophilus ducreyi_ . Among the gram-negative anacrobes more than half of all strains of _Bacteroides fragilis_ and many _Fusobacterium_ strains are resistant. Fungi yeast, and viruses are resistant to erythromycin. PHARMACOKINETICS Facilitated absorption with empty stomach with maximum peak concentration after one hour of administration with elimination half life of approximately 2 hours. Doses may be given up to 4 times a day. Erythromycin ethylsuccinate exhibits lower extent of ad Izlasiet visu dokumentu