Valsts: Singapūra
Valoda: angļu
Klimata pārmaiņas: HSA (Health Sciences Authority)
MIDAZOLAM
DKSH SINGAPORE PTE. LTD.
N05CD08
15 mg/3 ml
INJECTION
MIDAZOLAM 5 mg/ml
INTRAVENOUS, INTRAMUSCULAR
Prescription Only
CENEXI
ACTIVE
1988-04-27
1 DORMICUM ® Midazolam SHORT-ACTING BENZODIAZEPINE FOR PREMEDICATION, SEDATION, INDUCTION AND MAINTENANCE OF ANESTHESIA AMPOULES FOR INTRAVENOUS, INTRAMUSCULAR AND RECTAL ADMINISTRATION COMPOSITION _Active ingredient_ : midazolam as hydrochloride. Ampoules 15 mg/3 ml and 5 mg/5 ml for i.v., i.m. and rectal administration. The content of the vial is a clear liquid, practically free from particles and colourless to yellowish. _Excipients_ : sodium chloride, hydrochloric acid, sodium hydroxide, water for injection. Sterile product. PROPERTIES AND EFFECTS Dormicum has hypnotic and sedative effects characterized by a rapid onset and short duration. It also exerts anxiolytic, anticonvulsant and muscle-relaxant effects. Dormicum impairs psychomotor function after single and/or multiple doses but causes minimal haemodynamic changes. The central actions of benzodiazepines are mediated through an enhancement of the GABAergic neurotransmission at inhibitory synapses. In the presence of benzodiazepines the affinity of the GABA receptor for the neurotransmitter is enhanced through positive allosteric modulation resulting in an increased action of released GABA on the postsynaptic transmembrane chloride ion flux. Chemically, midazolam is a derivative of the imidazobenzodiazepine group. Although the free base is a lipophilic substance with low solubility in water. The basic nitrogen in position 2 of the imidazobenzodiazepine ring system enables the active ingredient of Dormicum to form water-soluble salts with acids. These produce a stable and well tolerated injection solution. This together with rapid metabolic transformation are the reasons for rapid onset and, because of rapid metabolic transformation, short duration of effects. Because of its low toxicity, midazolam has a wide therapeutic range. After parenteral administration anterograde amnesia of short duration occurs (the patient does not recall events that occurred during the peak of activity of the compound). PHARMACOKINETICS _Absorption after intramuscular injection Izlasiet visu dokumentu
1 INJ-DOR-2019 04-0 DORMICUM ® Midazolam SHORT-ACTING BENZODIAZEPINE FOR PREMEDICATION, SEDATION, INDUCTION AND MAINTENANCE OF ANESTHESIA AMPOULES FOR INTRAVENOUS, INTRAMUSCULAR AND RECTAL ADMINISTRATION COMPOSITION _Active ingredient_ : midazolam as hydrochloride. Ampoules 15 mg/3 ml and 5 mg/5 ml for i.v., i.m. and rectal administration. The content of the vial is a clear liquid, practically free from particles and colourless to yellowish. _Excipients_ : sodium chloride, hydrochloric acid, sodium hydroxide, water for injection. Sterile product. PROPERTIES AND EFFECTS Dormicum has hypotic and sedative effects characterized by a rapid onset and short duration. It also exerts anxiolytic, anticonvulsant and muscle-relaxant effects. Dormicum impairs psychomotor function after single and/or multiple doses, but causes minimal haemodynamic changes. The central actions of benzodiazepines are mediated through an enhancement of the GABAergic neurotransmission at inhibitory synapses. In the presence of benzodiazepines the affinity of the GABA receptor for the neurotransmitter is enhanced through positive allosteric modulation resulting in an increased action of released GABA on the postsynaptic transmembrane chloride ion flux. Chemically, midazolam is a derivative of the imidazobenzodiazepine group. Although the free base is a lipophilic substance with low solubility in water. The basic nitrogen in position 2 of the imidazobenzodiazepine ring system enables the active ingredient of Dormicum to form water-soluble salts with acids. These produce a stable and well tolerated injection solution. This together with rapid metabolic transformation are the reasons for rapid onset and, because of rapid metabolic transformation, short duration of effects. Because of its low toxicity, midazolam has a wide therapeutic range. After parenteral administration anterograde amnesia of short duration occurs (the patient does not recall events that occurred during the peak of activity of the compound). PHARMACOKINETICS _Absorption after intra Izlasiet visu dokumentu