DIAMIDE 2.5MG500MG FILM-COATED TABLET

Valsts: Malaizija

Valoda: angļu

Klimata pārmaiņas: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktīvā sastāvdaļa:

METFORMIN HYDROCHLORIDE; GLIBENCLAMIDE

Pieejams no:

HOVID BERHAD

SNN (starptautisko nepatentēto nosaukumu):

METFORMIN HYDROCHLORIDE; GLIBENCLAMIDE

Vienības iepakojumā:

120Tablet Tablets; 10Tablet Tablets

Ražojis:

HOVID BERHAD

Lietošanas instrukcija

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
DIAMIDE FILM-COATED TABLET
Glibenclamide/Metformin (5/500 mg, 2.5/500 mg)
1
WHAT IS IN THIS LEAFLET
1.
What Diamide tablet is used for
2.
How Diamide tablet works
3.
Before you use Diamide tablet
4.
How to use Diamide tablet
5.
While you are using Diamide tablet
6.
Side effects
7.
Storage and Disposal of Diamide
tablet
8.
Product description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
11.
Serial number
WHAT DIAMIDE TABLET IS USED FOR
This anti-diabetic medication is a
combination of two drugs (glibenclamide
and metformin). It is used along with a
diet and exercise program to control high
blood sugar in patients with type 2
diabetes (non- insulin-dependent
diabetes).
HOW DIAMIDE TABLET WORKS
Diamide tablet combines two glucose-
lowering drugs, glibenclamide and
metformin.
These two drugs work together to
improve the different metabolic defects
found in type 2 diabetes. Glibenclamide
lowers blood sugar primarily by causing
more of the body's own insulin to be
released, and metformin lowers blood
sugar, in part, by helping your body use
your own insulin more effectively.
Together, they are efficient in helping
you to achieve better glucose control.
BEFORE YOU USE DIAMIDE TABLET
_- When you must not use it _
You should not take Diamide tablet if:
•
You have kidney or liver problems
•
You have congestive heart failure
which is treated with medications,
eg, digoxin or furosemide
•
You drink alcohol excessively (all
the time or short-term "binge"
drinking)
•
You are seriously dehydrated (have
lost a large amount of body fluids)
•
You are going to have surgery
•
You develop a serious condition,
such as a heart attack, severe
infection, or stroke.
•
You have severely reduced kidney
function.
•
You have lactic acidosis (too much
lactic acid in the blood. See “risk of
lactic acidosis” below or
ketoacidosis. Ketoacidosis is a
condition in which substances called
‘ketone bodies’ accumulate in the
blood and which can lead to dia

Produkta apraksts

DESCRIPTION
DIAMIDE 2.5 MG / 500 MG FILM-COATED TABLET
White, oblong, transparent film-coated tablet, shallow convex
faces, "HD" embossed and scored at the same face.
DIAMIDE 5 MG / 500 MG FILM-COATED TABLET
Oblong, yellow film-coated tablet, shallow convex faces,
"HD" embossed and scored at the same face.
COMPOSITION
Each tablet contains:
DIAMIDE 2.5 MG / 500 MG FILM-COATED TABLET
Glibenclamide 2.5 mg, Metformin HCl 500 mg
DIAMIDE 5 MG / 500 MG FILM-COATED TABLET
Glibenclamide 5 mg, Metformin HCl 500 mg
PHARMACODYNAMICS
GLIBENCLAMIDE: Glibenclamide is a sulfonylurea antidiabetic.
It promotes the increased secretion of insulin from the beta
cells of islet tissue in the pancreas by means of a process
not yet specifically defined. The overall effect is a reduction
in blood glucose concentration only in those patients whose
pancreas is capable of synthesizing insulin. Oral antidiabetic
medications apparently do not influence the production of
insulin by the beta cells but seem to enhance its release
from these pancreatic cells.
METFORMIN HYDROCHLORIDE: Metformin is an oral biguanide
antidiabetic agent. Its mode of action is thought to be
multifactorial and includes delayed uptake of glucose from
the
gastro-intestinal
tract;
increased
peripheral
glucose
utilization mediated by increased insulin sensitivity; and
inhibition of increased hepatic and renal gluconeogenesis.
PHARMACOKINETICS
GLIBENCLAMIDE: Glibenclamide is readily absorbed from the
gastrointestinal tract, peak plasma concentrations usually
occurring within 2 to 4 hours, and is extensively bound to
plasma
proteins.
Absorption
may
be
slower
in
hyperglycaemic patients and may differ according to the
particle size of the preparation used. It is metabolized,
almost completely, in the liver, the principal metabolite being
only very weakly active. Approximately 50% of a dose is
excreted in the urine and 50% via the bile into the faeces.
METFORMIN
HYDROCHLORIDE:
Metformin
Hydrochloride
is
slowly and incompletely absorbed from the gastrointestinal
tract. The absolu