Valsts: Izraēla
Valoda: angļu
Klimata pārmaiņas: Ministry of Health
MAROPITANT AS CITRATE MONOHYDRATE
ZOETIS ISRAEL HOLDING B.V., ISRAEL
SOLUTION FOR INJECTION
MAROPITANT AS CITRATE MONOHYDRATE 10 MG/ML
S.C
Required
FAREVA AMBOISE, FRANCE
In dogs above age 8 weeks and cats above age 16 weeks : for the prevention of vomiting except that induced by motion sickness.For the treatment of vomiting, in combination with other supportive measures.Dogs age 8 - 10 weeks must be under close medical supervision or hospitalized.
2015-03-31
תושקובמה תורמחהה ןולעב קרפ יחכונ טסקט שדח טסקט INDICATION N/A N/A CONTRAINDICATIONS N/A N/A POSOLOGY, DOSAGE & ADMINISTRATION N/A N/A SPECIAL WARNINGS AND SPECIAL PRECAUTIONS FOR USE N/A Dogs: Although Cerenia Injection Veterinary has been demonstrated to be effective in both the treatment and prevention of emesis induced by chemotherapy, it was found more efficacious if used preventively. Therefore, it is recommended to administer the antiemetic prior to administration of the chemotherapeutic agent. Use only according to the benefit-risk assessment by the responsible veterinarian. As maropitant is accumulated in the body during a 14 day treatment period due to metabolic saturation, careful monitoring of liver function and any adverse events should be implemented during long term treatment. Cerenia Injection Veterinary should be used with caution in animals suffering from or with predisposition for cardiac diseases as maropitant has affinity to Ca- and K-ion channels. Increases of approximately 10% in the QT interval of the ECG were observed in a study on healthy beagle dogs administered 8 mg/kg orally; however, such an increase is unlikely to be of clinical significance. In laboratory studies, maropitant has been shown to be a potential eye irritant. INTERACTION WITH OTHER MEDICAMENTS AND OTHER FORMS OF INTERACTION N/A N/A FERTILITY, PREGNANCY AND LACTATION N/A N/A ADVERSE EVENTS יאוול תועפות לש הרקמ לכב תעפות לש הרקמב וא הרומח ךילע ,ןולעב הרכזוה אלש יאוול רנירטווה אפורה םע ץעייתהל .דימ Izlasiet visu dokumentu
because conclusive reproductive toxicity studies have not been conducted in any animal species. 4.8 INTERACTION WITH OTHER MEDICINAL PRODUCTS AND OTHER FORMS OF INTERACTION Cerenia Injection Veterinary should not be used concomitantly with Ca-channel antagonists as maropitant has affinity to Ca- channels. Maropitant is highly bound to plasma proteins and may compete with other highly bound medicines. 4.9 AMOUNTS TO BE ADMINISTERED AND ADMINISTRATION ROUTE For subcutaneous use in dogs and cats. Cerenia Injection Veterinary should be injected subcutaneously, once daily, at a dose of 1 mg/kg bodyweight (1 ml/10 kg bodyweight) for up to 5 consecutive days. In dogs, Cerenia Injection Veterinary can be used to treat or prevent vomiting when administered once daily. Cerenia Injection Veterinary may be administered for up to five days. To prevent vomiting, Cerenia Injection Veterinary solution for injection should be administered more than 1 hour in advance. The effect duration is approximately 24 h and therefore treatment can be given the night before administration of an agent that may cause emesis, e.g. chemotherapy. As the pharmacokinetic variation is large and maropitant accumulates in the body after once-daily repeated administration, lower doses than recommended might be sufficient in some individuals and when repeating the dose. 4.10 OVERDOSE (SYMPTOMS, EMERGENCY PROCEDURES, ANTIDOTES), IF NECESSARY Apart from transient reactions at the injection site following subcutaneous administration, Cerenia Injection Veterinary was well tolerated in dogs and young cats injected daily with up to 5 mg/kg (5 times the recommended dose) for 15 consecutive days (3 times the recommended duration of administration). No data have been presented on overdoses in adult cats. 4.11 WITHDRAWAL PERIOD(S) Not applicable. 5. PHARMACOLOGICAL PROPERTIES Pharmacotherapeutic group: Antiemetics. ATCvet code: QA04AD90. Maropitant is a potent and selective neurokinin (NK 1 ) receptor antagonist, which acts by inhibiting the binding of substance P Izlasiet visu dokumentu