Valsts: Austrālija
Valoda: angļu
Klimata pārmaiņas: Department of Health (Therapeutic Goods Administration)
fosinopril sodium,hydrochlorothiazide
Medis Pharma Pty Ltd
Fosinopril sodium,Hydrochlorothiazide
Registered
APO-Fosinopril HCTZ 20/12.5 CMI July 2014 APO-FOSINOPRIL HCTZ 20/12.5 TABLETS _contain the active ingredients fosinopril sodium and hydrochlorothiazide _ _CONSUMER MEDICINE INFORMATION _ WHAT IS IN THIS LEAFLET This leaflet answers some common questions about APO- FOSINOPRIL HCTZ 20/12.5. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. KEEP THIS LEAFLET. You may need to read it again. IF YOU HAVE ANY CONCERNS ABOUT TAKING APO-FOSINOPRIL HCTZ 20/12.5, ASK YOUR DOCTOR OR PHARMACIST. WHAT APO- FOSINOPRIL HCTZ 20/12.5 IS USED FOR APO-FOSINOPRIL HCTZ 20/12.5 is used to lower high blood pressure (hypertension). Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. If you have hypertension (high blood pressure), this means that your blood pressure stays higher than is needed, even when you are relaxed. There are usually no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems, including stroke, heart disease and kidney failure. _HOW APO-_ _FOSINOPRIL HCTZ _ _20/12.5 WORKS _ APO-FOSINOPRIL HCTZ 20/12.5 tablets contain two medicines, fosinopril sodium and hydrochlorothiazide. Both medicines reduce blood pressure, but work different ways. Fosinopril sodium belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors. It works by widening your blood vessels, reducing the pressure in the vessels (reducing 'blood pressure') and by making it easier for your heart to pump blood around your body. This helps your heart to work better by increasing the supply of oxygen to your heart. Hydrochlorothiazide is a diuretic (fluid tablet). It helps reduce the amount of excess fluid in the body by increasing the amount of urine produced. It also low Izlasiet visu dokumentu
_APO-FOSINOPRIL HCTZ 20/12.5 _ PRODUCT INFORMATION NAME OF THE MEDICINE APO-Fosinopril HCTZ 20/12.5 contains two active drug substances: fosinopril sodium and hydrochlorothiazide. _FOSINOPRIL SODIUM_, chemical name: L-Proline, 4-cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy) propoxy] (4-phenylbutyl) phosphinyl]acetyl]-, sodium salt, _trans-. _ Molecular formula is C 30 H 45 NNaO 7 P. Molecular weight is 585.65. Fosinopril sodium chemical abstract number CAS is 88889-14-9. _HYDROCHLOROTHIAZIDE_, chemical name: 6-chloro-3,4-dihydro- 2_H_-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Molecular formula is C 7 H 8 CIN 3 O 4 S 2 . Molecular weight is 297.72. The chemical abstract number CAS is 58-93-5. _PRODUCT INFORMATION: APO-FOSINOPRIL HCTZ 20/12.5 _ PI 110614 DESCRIPTION Fosinopril sodium is a white to off white crystalline powder. It is soluble in water (100 mg/mL) methanol and ethanol and slightly soluble in hexane. Hydrochlorothiazide is the 3,4-dihydro derivative of chlorothiazide. It is a white or practically white, crystalline powder which is very slightly soluble in water, soluble in acetone; sparingly soluble in ethanol (96%) but it dissolves in dilute solutions of alkali hydroxides. Each tablet contains 20 mg fosinopril sodium and 12.5 mg hydrochlorothiazide. The tablet also contains the following excipients: lactose, pregelatinised starch, croscarmellose sodium, glycerol dibehenate, magnesium stearate and pigment blend PB-23061. PHARMACOLOGY FOSINOPRIL SODIUM Fosinopril sodium is the ester prodrug of a long acting angiotensin converting enzyme (ACE) inhibitor, fosinopril diacid. It is a subclass of ACE inhibitors containing a phosphinate group which makes it different from other marketed ACE inhibitors. In humans and animals, fosinopril sodium following absorption is hydrolysed to the pharmacologically active fosinopril diacid, a specific competitive inhibitor of angiotensin converting enzyme (ACE). ACE, a peptidyldipeptidase, catalyses the conversion of the decapeptide angiotensin I to the octapeptide ang Izlasiet visu dokumentu