ALLOPURINOL tablet

Valsts: Amerikas Savienotās Valstis

Valoda: angļu

Klimata pārmaiņas: NLM (National Library of Medicine)

Aktīvā sastāvdaļa:

ALLOPURINOL (UNII: 63CZ7GJN5I) (ALLOPURINOL - UNII:63CZ7GJN5I)

Pieejams no:

St Marys Medical Park Pharmacy

SNN (starptautisko nepatentēto nosaukumu):

ALLOPURINOL

Kompozīcija:

ALLOPURINOL 300 mg

Receptes veids:

PRESCRIPTION DRUG

Autorizācija statuss:

Abbreviated New Drug Application

Produkta apraksts

ALLOPURINOL- ALLOPURINOL TABLET
ST MARYS MEDICAL PARK PHARMACY
----------
ALLOPURINOL TABLETS, USP
100 MG AND 300 MG
RX ONLY
DESCRIPTION
Allopurinol has the following structural formula:
C
H
N
O M.W. = 136.11
Allopurinol is known chemically as 1, 5-dihydro- _4H_-pyrazolo [3, 4-
_d_] pyrimidin-4-one. It is a xanthine
oxidase inhibitor which is administered orally. Its solubility in
water at 37°C is 80.0 mg/dL and is
greater in an alkaline solution. Each scored white to off-white tablet
contains 100 mg allopurinol and
the inactive ingredients lactose monohydrate, corn starch, sodium
starch glycolate, povidone and stearic
acid. Each scored peach tablet contains 300 mg allopurinol and the
inactive ingredients lactose
monohydrate, corn starch, sodium starch glycolate , FD & C yellow no.
6, povidone and stearic acid.
CLINICAL PHARMACOLOGY
Allopurinol acts on purine catabolism, without disrupting the
biosynthesis of purines. It reduces the
production of uric acid by inhibiting the biochemical reactions
immediately preceding its formation.
Allopurinol is a structural analogue of the natural purine base,
hypoxanthine. It is an inhibitor of
xanthine oxidase, the enzyme responsible for the conversion of
hypoxanthine to xanthine and of xanthine
to uric acid, the end product of purine metabolism in man. Allopurinol
is metabolized to the
corresponding xanthine analogue, oxipurinol (alloxanthine), which also
is an inhibitor of xanthine
oxidase.
5
4
4
It has been shown that reutilization of both hypoxanthine and xanthine
for nucleotide and nucleic acid
synthesis is markedly enhanced when their oxidations are inhibited by
allopurinol and oxipurinol. This
reutilization does not disrupt normal nucleic acid anabolism, however,
because feedback inhibition is an
integral part of purine biosynthesis. As a result of xanthine oxidase
inhibition, the serum concentration
of hypoxanthine plus xanthine in patients receiving allopurinol
tablets for treatment of hyperuricemia is
usually in the range of 0.3 to 0.4 mg/dL compared to a normal le