Allopurinol 300mg tablets

Valsts: Lielbritānija

Valoda: angļu

Klimata pārmaiņas: MHRA (Medicines & Healthcare Products Regulatory Agency)

Aktīvā sastāvdaļa:

Allopurinol

Pieejams no:

Sandoz Ltd

ATĶ kods:

M04AA01

SNN (starptautisko nepatentēto nosaukumu):

Allopurinol

Deva:

300mg

Zāļu forma:

Oral tablet

Ievadīšanas:

Oral

Klase:

No Controlled Drug Status

Receptes veids:

Valid as a prescribable product

Produktu pārskats:

BNF: 10010400

Lietošanas instrukcija

Package leaflet: Information for the user
ALLOPURINOL TABLETS BP 300MG
(allopurinol)
anyother medicines.
•
medicines used to reduce your immune
response (immunosuppressant) e.g.
azathiopine, ciclosporin
•
antibiotics e.g. amoxicillin or ampicillin
•
aspirin
•
theophylline, used for breathing problems
•
medicines used for fits (epilepsy) e.g.
phenytoin
This includes medicines obtained without a
prescription, including herbal medicines. This is
because Allopurinol Tablets can affect the way
some medicines work. Also some other
medicines can affect the way Allopurinol tablets
work. For example -
•
vidarabine, used to treat herpes or
chickenpox
•
didanosine, used to treat HIV infection
•
medicines used to treat diabetes e.g.
chlorpropamide
•
6-mercaptopurine used to treat cancer of the
blood cells
•
medicines used to thin your blood
(anticoagulants) such as warfarin
•
medicines for heart problems or high blood
pressure such as ’ACE inihibitors’ or water
tablets (diuretics)
•
any other medicine to treat gout e.g.
probenecid
If you or someone else swallow several of these
tablets together, contact your doctor or nearest
hospital emergency department immediately.
Always take the box, this leaflet and any tablets
that are left over with you, if you can. Signs of an
overdose may include nausea, vomiting,
diarrhoea and dizziness.
The recommended dose is 10 to 20 milligrams
per kilogram body weight/day up to a maximum of
400mg daily.
Blood count monitoring should therefore be
performed at regular intervals.
USE IN PATIENTS ON KIDNEY DIALYSIS:
ALLOPURINOL TABLET CONTAINS
LACTOSE
USE IN THE ELDERLY: (OVER 65 YEARS)
ADULTS:(OVER 18 YEARS)
PREGNANCY AND BREAST-FEEDING
DRIVING AND USING MACHINES
Allopurinol Tablets may cause
drowsiness, affect your co-
ordination, affect your vision or make
you feel dizzy. If you experience
these symptoms you should avoid
driving or operating machinery.
The recommended dose ranges from 100 to 900
mg each day. Initially 100 to 300mg per day is
taken as a single dose

Produkta apraksts

SUMMARY OF PRODUCT CHARACTERISTICS
1
NAME OF THE MEDICINAL PRODUCT
Allopurinol 300mg Tablets
2.
QUALITATIVE AND QUANTITATIVE COMPOSITION
Each tablet contains 300 mg Allopurinol.
Excipient(s) with known effect
Each tablet contains 180 mg lactose (as monohydrate) and 3.5 mg sodium
laurilsulfate.
For the full list of excipients, see section 6.1.
3
PHARMACEUTICAL FORM
Tablet
White, biconvex tablets engraved: BERK 2K1 or 2K1 plain on reverse.
4 CLINICAL PARTICULARS
4.1.
THERAPEUTIC INDICATIONS
Allopurinol is indicated for reducing urate/uric acid formation in
conditions where
urate/uric acid deposition has already occurred (e.g. skin tophi,
gouty arthritis, and
nephrolithiasis) or is a predictable clinical risk (e.g. treatment of
malignancy potentially
leading to acute uric acid nephropathy). The main clinical conditions
where urate/uric
acid deposition may occur are: uric acid liathiasis; idiopathic gout;
acute uric acid
nephropathy; neoplastic disease and myeloproliferative disease with
high cell turnover
rates, in which high urate levels occur either spontaneously, or after
cytotoxic therapy;
certain
enzyme
disorders
which
lead
to
overproduction
of
urate,
for
example:
hypoxanthine-guanine
phosphoribosyltransferase,
including
Lesch-Nyhan
syndrome;
glucose-6-phosphatase
including
glycogen
storage
disease;
phosphoribosylpyrophosphate
synthetase;
phosphoribosylpyrophosphate
amidotransferase; adenine phosphoribosyltransferase. Allopurinol is
also indicated for
the management of 2,8-dihydroxyadenine (2,8-DHA) renal stones related
to deficient
activity of adenine phosphoribosyltransferase. Allopurinol is also
indicated for the
management
of
recurrent
mixed
calcium
oxalate
renal
stones
in
the
presence
of
hyperuricosuria, when fluid, dietary and similar measures have failed.
4.2.
POSOLOGY AND METHOD OF ADMINISTRATION
Posology
Dosage should be modified by monitoring serum urate concentrations and
urinary
urate/uric acid levels at appropriate intervals.
Dose frequency:
Allopurinol may be taken orally once a day after a meal.