PROBENECID tablet, film coated

Šalis: Jungtinės Valstijos

kalba: anglų

Šaltinis: NLM (National Library of Medicine)

Veiklioji medžiaga:

Probenecid (UNII: PO572Z7917) (Probenecid - UNII:PO572Z7917)

Prieinama:

HHS/Program Support Center/Supply Service Center

INN (Tarptautinis Pavadinimas):

Probenecid

Sudėtis:

Probenecid 500 mg

Vartojimo būdas:

ORAL

Recepto tipas:

PRESCRIPTION DRUG

Terapinės indikacijos:

For treatment of the hyperuricemia associated with gout and gouty arthritis. As an adjuvant to therapy with penicillin or with ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin, for elevation and prolongation of plasma levels by whatever route the antibiotic is given. Hypersensitivity to probenecid. Children under 2 years of age. Not recommended in persons with known blood dyscrasias or uric acid kidney stones. Therapy with probenecid should not be started until an acute gouty attack has subsided.

Produkto santrauka:

Probenecid Tablets USP 500 mg are bisected, capsule-shaped, yellow, film-coated tablets imprinted DAN DAN and 5347 Dispense in well-closed container with child-resistant closure. Store at 20°-25° (68°-77°F). [See USP controlled room temperature.] Manufactured By: Watson Pharma Private Ltd. Verna, Salcette Goa 403 722 INDIA Distributed By: Watson Pharma, Inc. Corona, CA 92880 USA Revised: June 2009                                                                                             190811                                                                                             0609B Repackaged by: HHS Supply Service Center Perry Point, MD 21902

Autorizacija statusas:

Abbreviated New Drug Application

Prekės savybės

PROBENECID- PROBENECID TABLET, FILM COATED
HHS/PROGRAM SUPPORT CENTER/SUPPLY SERVICE CENTER
----------
PROBENECID TABLETS USP
REVISED: JUNE 2009
RX ONLY
190811
DESCRIPTION
Probenecid is a uricosuric and renal tubular transport blocking agent.
Probenecid is the generic name for 4-[(dipropyl-amino)sulfonyl]
benzoic acid. It has the following
structural formula:
C
H NO S M.W. 285.36
Probenecid is a white or nearly white, fine, crystalline powder.
Probenecid is soluble in dilute alkali, in
alcohol, in chloroform, and in acetone; it is practically insoluble in
water and in dilute acids.
Probenecid Tablets USP 500 mg contain the following inactive
ingredients: colloidal silicon dioxide,
D&C Yellow No. 10, FD&C Blue No. 1, FD&C Yellow No. 6, hypromellose,
magnesium stearate,
microcrystalline cellulose, polyethylene glycol, polysorbate 80,
sodium lauryl sulfate, sodium starch
glycolate and titanium dioxide.
CLINICAL PHARMACOLOGY
Probenecid is a uricosuric and renal tubular blocking agent. It
inhibits the tubular reabsorption of urate,
thus increasing the urinary excretion of uric acid and decreasing
serum urate levels. Effective
uricosuria reduces the miscible urate pool, retards urate deposition,
and promotes resorption of urate
deposits.
Probenecid inhibits the tubular secretion of penicillin and usually
increases penicillin plasma levels by
any route the antibiotic is given. A 2-fold to 4-fold elevation has
been demonstrated for various
penicillins.
Probenecid has also been reported to inhibit the renal transport of
many other compounds including
aminohippuric acid (PAH), aminosalicylic acid (PAS), indomethacin,
sodium iodomethamate and related
iodinated organic acids, 17-ketosteroids, pantothenic acid,
phenolsulfonphthalein (PSP), sulfonamides,
and sulfonylureas. See also DRUG INTERACTIONS.
Probenecid decreases both hepatic and renal excretion of
sulfobromophthalein (BSP). The tubular
reabsorption of phosphorus is inhibited in hypoparathyroid but not in
euparathyroid individuals.
Probenecid does not influence plasma