Šalis: Jungtinės Valstijos
kalba: anglų
Šaltinis: NLM (National Library of Medicine)
POLYMYXIN B SULFATE (UNII: 19371312D4) (POLYMYXIN B - UNII:J2VZ07J96K)
Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC
POLYMYXIN B SULFATE
POLYMYXIN B 10000 [USP'U] in 1 mL
PRESCRIPTION DRUG
Abbreviated New Drug Application
POLYMYXIN B SULFATE AND TRIMETHOPRIM- POLYMYXIN B SULFATE AND TRIMETHOPRIM SULFATE SOLUTION/ DROPS LAKE ERIE MEDICAL & SURGICAL SUPPLY DBA QUALITY CARE PRODUCTS LLC ---------- POLYMYXIN B SULFATE AND TRIMETHOPRIM OPHTHALMIC SOLUTION USP DESCRIPTION Polymyxin B Sulfate and Trimethoprim Ophthalmic Solution USP* is a sterile antimicrobial solution for topical ophthalmic use. It has a pH of 4.0 to 6.2 and osmolality of 270 to 310 mOsm/kg. Trimethoprim sulfate, a white, odorless, crystalline powder, is represented by the following structural formula: C H N O S Mol. Wt. 678.72 Chemical Name: Trimethoprim sulfate, 2,4-diamino-5-(3,4 5-trimethoxybenzyl)pyrimidine sulfate (2:1) Polymyxin B sulfate is the sulfate salt of polymyxin B and B which are produced by the growth of _Bacilluspolymyxa _(Prazmowski) Migula (Fam. Bacillaceae) . It has a potency of not less than 6,000 polymyxin B units per mg, calculated on an anhydrous basis. The structural formula is: EACH ML CONTAINS: ACTIVES: Polymyxin B Sulfate equal to 10,000 polymyxin B units, Trimethoprim Sulfate (equivalent to trimethoprim 1 mg); INACTIVES: Sodium Chloride, Purified Water. Sulfuric acid and, if necessary, sodium hydroxide may be added to adjust pH (4.0 – 6.2). PRESERVATIVE ADDED: Benzalkonium Chloride 0.004%. CLINICAL PHARMACOLOGY Trimethoprim is a synthetic antibacterial drug active against a wide variety of aerobic gram-positive and gram-negative ophthalmic pathogens. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. This binding is stronger for the bacterial enzyme than for the corresponding mammalian enzyme and therefore selectively interferes with bacterial biosynthesis of nucleic acids and proteins. Polymyxin B, a cyclic lipopeptide antibiotic, is bactericidal for a variety of gram-negative organisms, especially _Pseudomonas aeruginosa_. It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components o Perskaitykite visą dokumentą