PMS-ADENOSINE SOLUTION

Šalis: Kanada

kalba: anglų

Šaltinis: Health Canada

Veiklioji medžiaga:

ADENOSINE

Prieinama:

PHARMASCIENCE INC

ATC kodas:

C01EB10

INN (Tarptautinis Pavadinimas):

ADENOSINE

Dozė:

3MG

Vaisto forma:

SOLUTION

Sudėtis:

ADENOSINE 3MG

Vartojimo būdas:

INTRAVENOUS

Vienetai pakuotėje:

2 ML

Recepto tipas:

Prescription

Gydymo sritis:

MISCELLANEOUS THERAPEUTIC AGENTS

Produkto santrauka:

Active ingredient group (AIG) number: 0113219001; AHFS:

Autorizacija statusas:

APPROVED

Leidimo data:

2001-02-23

Prekės savybės

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pms-ADENOSINE_ Product Monograph _
_Page 1 of 23_
PRODUCT MONOGRAPH
PR
PMS-ADENOSINE
Adenosine Injection, USP
3 mg/mL
(6 mg / 2 mL Vial)
Antiarrhythmic
PHARMASCIENCE INC.
6111 Royalmount Ave., Suite 100
Montreal, Quebec
H4P 2T4
Date of Revision:
December 11, 2013
WWW.PHARMASCIENCE.COM
Submission Control No: 165189
_ _
pms-ADENOSINE_ Product Monograph _
_Page 2 of 23_
PRODUCT MONOGRAPH
PR
PMS-ADENOSINE
Adenosine Injection, USP
3 mg/mL
(6 mg / 2 mL Vial)
THERAPEUTIC CLASSIFICATION
Antiarrhythmic
ACTION AND CLINICAL PHARMACOLOGY
Adenosine is an endogenous nucleoside occurring in all cells of the
body. When injected
intravenously adenosine slows atrioventricular (A-V) nodal conduction,
can interrupt the reentry
pathways through the A-V node and can restore normal sinus rhythm in
patients with paroxysmal
supraventricular tachycardia (PSVT), including PSVT associated with
Wolff-Parkinson-White
syndrome.
Adenosine is antagonized competitively by methylxanthines such as
caffeine and theophylline
and potentiated by blockers of nucleoside transport such as
dipyridamole. Adenosine is not
blocked by atropine.
In controlled clinical trials, cumulative 60% and 92% of patients
converted to normal sinus
rhythm within one minute after 6 mg and 12 mg bolus doses of
adenosine, respectively. In other
controlled clinical trials with bolus doses of 3, 6, 9 and 12 mg some
patients with paroxysmal
supraventricular tachycardia converted to normal sinus rhythm on 3 mg
of adenosine. Reports in
the medical literature indicate success in treating PSVT in pediatric
patients (including
newborns) with adenosine in doses equivalent by weight to those used
in adults.
_ _
pms-ADENOSINE_ Product Monograph _
_Page 3 of 23_
Adenosine is not effective in converting rhythms other than PSVT, such
as atrial flutter, atrial
fibrillation, or ventricular tachycardia to normal sinus rhythm.
Hemodynamics
Adenosine is a potent vasodilator in most vascular beds, except in
renal afferent arterioles and
hepatic veins where it produces vasoconstriction. The in