PERINDOPRIL AND INDAPAMIDE-BW 4/1.25 mg TABLETS perindopril erbumine 4mg and indapamide hemihydrate1.25mg tablet blister pack

Šalis: Australija

kalba: anglų

Šaltinis: Department of Health (Therapeutic Goods Administration)

Veiklioji medžiaga:

indapamide hemihydrate,perindopril erbumine

Prieinama:

Lupin Australia Pty Limited

INN (Tarptautinis Pavadinimas):

indapamide hemihydrate,Perindopril erbumine

Autorizacija statusas:

Registered

Pakuotės lapelis

PERINDOPRIL AND INDAPAMIDE-BW
4/1.25 MG TABLETS
Perindopril erbumine and indapamide hemihydrate.
(Lupin Australia Pty. Ltd.)
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common questions about Perindopril and
Indapamide-BW 4/1.25 mg
tablets. It does not contain all the available information about this
medicine.
Reading this leaflet does
not take the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the
risks of you taking Perindopril
and Indapamide-BW 4/1.25 mg tablets against the expected benefits for
you.
IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR
OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT PERINDOPRIL AND INDAPAMIDE-BW 4/1.25 MG TABLETS IS
Perindopril and Indapamide-BW 4/1.25 mg tablets. The medicine contains
the active ingredients
perindopril erbumine and indapamide hemihydrate. Perindopril belongs
to a group of medicines called
angiotensin converting enzyme (ACE) inhibitors. Indapamide belongs to
a group of medicines called
chlorosulphamoyl diuretics.
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Page 2 of 9
WHAT PERINDOPRIL AND INDAPAMIDE-BW 4/1.25 MG TABLETS IS
USED FOR
Perindopril and Indapamide-BW 4/1.25 mg tablets are available only
with a doctor's prescription.
There is no evidence that Perindopril and Indapamide-BW 4/1.25 mg
tablets are addictive.
WHY PERINDOPRIL AND INDAPAMIDE-BW 4/1.25 MG TABLETS 4/1.25 MG IS USED
FOR HIGH BLOOD
PRESSURE
Everyone has blood pressure. This pressure helps to circulate blood
all around the body. Your blood
pressure may be different at different times of the day, depending on
how busy or stressed you are.
You have high blood pressure (also known as hypertension) when your
blood pressure stays higher
than is needed, even when you are calm and relaxed.
If high blood pressure is not treated it can lead to serious health
problems. You may feel

Prekės savybės

PERINDOPRIL AND INDAPAMIDE-BW 4 /1.25 mg TABLETS
(LUPIN AUSTRALIA PTY. LTD)
NAME OF THE MEDICINE
Perindopril and Indapamide-BW 4 /1.25 mg Tablets containing
perindopril erbumine 4mg
and indapamide hemihydrate 1.25mg
DESCRIPTION
Perindopril erbumine
It is described chemically as tert-butylammonium (2S, 3aS,
7aS)-1-(N-[(S)-1-ethoxycarbonyl
butyl]-L-alanyl)
perhydroindole-2-carboxylate.
Perindopril
is
a
dipeptide
monoacid
monoester with a perhydroindole group and no sulphydryl radical.
Perindopril erbumine is
a white powder, readily soluble in purified water, ethanol and
chloroform. Perindopril
erbumine has five asymmetric centres. The drug is synthesised
stereoselectively so that it is
a single enantiomer (all S stereochemistry).
Molecular formula: C
19
H
32
N
2
O
5
, C
4
H
11
N
Molecular Weight: 441.6
CAS: 107133-36-8
Perindopril erbumine: Chemical structure.
Indapamide hemihydrate
Indapamide hemihydrate is 4-chloro-N-(2
methyl-1-indolinyl)-3-sulphamoyl benzamide
hemihydrate.
Empirical formula: C
16
H
16
ClN
3
O
3
S, ½ H
2
O
Molecular Weight: 365. 84
CAS: 26807-65-8
Indapamide
hemihydrate
is
white
crystalline
lipophilic
powder,
soluble
in
methanol,
ethanol, acetic acid and ethyl acetate, very slightly soluble in
ether, chloroform and
benzene and practically insoluble in water.
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_Lupin Australia Pty Ltd _
Page 2 of 22
Chemical structure of anhydrous indapamide:
Excipients
Lactose, microcrystalline cellulose, hydrophobic colloidal anhydrous
silica, magnesium
stearate.
PHARMACOLOGY
Mechanism of Action
Perindopril and Indapamide tablets 4/1.25 mg are a combination of
perindopril erbumine,
an angiotensin converting enzyme (ACE) inhibitor, and indapamide, a
chlorosulphamoyl
diuretic, in which the doses of the ACE inhibitor and diuretic
components are up to two
times lower than the usual dose used for monotherapy. Its
pharmacological properties are
derived from each of its components, in addition to those due to the
synergistic action of