Šalis: Jungtinės Valstijos
kalba: anglų
Šaltinis: NLM (National Library of Medicine)
Neomycin Sulfate (UNII: 057Y626693) (Neomycin - UNII:I16QD7X297), Polymyxin B Sulfate (UNII: 19371312D4) (Polymyxin B - UNII:J2VZ07J96K), Bacitracin Zinc (UNII: 89Y4M234ES) (Bacitracin - UNII:58H6RWO52I)
Akorn
Neomycin Sulfate
Neomycin 3.5 mg in 1 g
OPHTHALMIC
PRESCRIPTION DRUG
Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment. USP is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment, USP is contraindicated in individuals who have shown hypersensitivity to any of its components.
Tube of 1/8 oz. (3.5 g) with ophthalmic tip. NDC 17478-235-35 Storage: Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Akorn Manufactured by: Akorn, Inc. Lake Forest, IL 60045 NPB00N Rev. 06/16
Abbreviated New Drug Application
NEOMYCIN AND POLYMYXIN B SULFATES, AND BACITRACIN ZINC- NEOMYCIN SULFATE, POLYMYXIN B SULFATE AND BACITRACIN ZINC OINTMENT AKORN ---------- NEOMYCIN AND POLYMYXIN B SULFATES AND BACITRACIN ZINC OPHTHALMIC OINTMENT, USP Rx only DESCRIPTION: Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment, USP is a sterile antimicrobial ointment for ophthalmic use. Each gram contains: Neomycin Sulfate (equivalent to 3.5 mg neomycin base), Polymyxin B sulfate equal to 10,000 polymyxin B units, bacitracin zinc equal to 400 bacitracin units, and white petrolatum, q.s. Neomycin sulfate is the sulfate salt of neomycin B and C, which are produced by the growth of _Streptomyces fradiae_ Waksman (Fam. Streptomycetaceae). It has a potency equivalent of not less than 600 meg of neomycin standard per mg, calculated on an anhydrous basis. The structural formula are: Polymyxin B sulfate is the sulfate salt of polymyxin B , and B , which are produced by the growth of _Bacillus polymyxa_ (Prazmowski) Migula (Fam. Bacillaceae). It has a potency of not less than 6,000 polymyxin B units per mg, calculated on an anhydrous basis. The structural formulae are: Bacitracin zinc is the zinc salt of bacitracin, a mixture of related cyclic polypeptides (mainly bacitracin A) produced by the growth of an organism of the _licheniformis_ group of _Bacillus subtilis_ var Tracy. It has a potency of not less than 40 bacitracin units per mg. The structural formula is: 1 2 CLINICAL PHARMACOLOGY A wide range of antibacterial action is provided by the overlapping spectra of neomycin, polymyxin B sulfate, and bacitracin. Neomycin is bactericidal for many gram-positive and gram-negative organisms. It is an aminoglycoside antibiotic, which inhibits protein synthesis by binding with ribosomal RNA and causing misreading of the bacterial genetic code. Polymyxin B is bactericidal for a variety of gram-negative organisms. It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane. Bacit Perskaitykite visą dokumentą