Maxima MUPS 20 Mups Tablet

Šalis: Bangladešas

kalba: anglų

Šaltinis: DGDA (Directorate General of Drug Administration)

Veiklioji medžiaga:

Esomeprazole

Prieinama:

The ACME Laboratories Ltd.

INN (Tarptautinis Pavadinimas):

Esomeprazole

Dozė:

20 mg

Vaisto forma:

Mups Tablet

Pakuotės lapelis

COMPOSITION
Each
MUPS
(Multiple-Unit
Pellet
System)
tablet
contains
133.333 mg Esomeprazole 15% w/w enteric coated pellets
(as Esomeprazole Magnesium Trihydrate USP) equivalent to
20 mg Esomeprazole.
MUPS
MUPS
is
abbreviation
for
Multiple-Unit
Pellet
System.
However,
from
pharmaceutical
industry
and
research
perspective, the term in general refers to MUPS compacted
into
tablets.
Thus,
the
resulting
tablets
prepared
by
compaction of modified release coated multiparticulates of
pellets
are
called
as
MUPS.
It
is
the
more
recent
and
challenging technologies that combine the advantages of both
tablets and pellet-filled capsules in one dosage form.
PHARMACOLOGY
Esomeprazole is a proton pump inhibitor that suppresses
gastric acid secretion by specific inhibition of the H+/K+-
ATPase
in
the
gastric
parietal
cell
thus
reducing
gastric
acidity. After oral administration, peak plasma levels (C
max
)
occur at approximately 1.5 hours (T
max
). At repeated once-
daily
dosing
with
40
mg,
the
systemic
bioavailability
is
approximately 90%. Esomeprazole is 97% bound to plasma
proteins. Esomeprazole is extensively metabolized in the liver
by
the
cytochrome
P450
(CYP)
enzyme
system.
Approximately
80%
of
an
oral
dose
of
Esomeprazole
is
excreted
as
inactive
metabolites
in
the
urine,
and
the
remainder is found as inactive metabolites in the feces.
CLINICAL
ADVANTAGE
OF
ESOMEPRAZOLE
MUPS
TABLET
COMPARED
TO
CONVENTIONAL
MODIFIED-
RELEASE
ESOMEPRAZOLE
TABLETS
AND
PELLET-
FILLED ESOMEPRAZOLE CAPSULES

Ensures greater bioavailablility

Ensures
uniform
emptying
of
micro
pellets
from
stomach into small intestine facilitates rapid dissolution
of enteric coating and drug release resulting in early
T
max
and
C
max
(peak
time
and
peak
plasma
concentration)

Ensure lesser possibility of dose dumping

Is a combination of fast acting and sustained action

Ensures uniform drug release

Once daily dosing

Ensures lesser chance of localized irritation

Ensures better and more uniform drug absorption

Is better than capsules i