Šalis: Jungtinės Valstijos
kalba: anglų
Šaltinis: NLM (National Library of Medicine)
ETHOSUXIMIDE (UNII: 5SEH9X1D1D) (ETHOSUXIMIDE - UNII:5SEH9X1D1D)
Avera McKennan Hospital
ETHOSUXIMIDE
ETHOSUXIMIDE 250 mg
PRESCRIPTION DRUG
Abbreviated New Drug Application
ETHOSUXIMIDE- ETHOSUXIMIDE CAPSULE AVERA MCKENNAN HOSPITAL ---------- ETHOSUXIMIDE CAPSULES, USP DESCRIPTION Ethosuximide is an anticonvulsant succinimide, chemically designated as alpha-ethyl-alpha-methyl- succinimide, with the following structural formula: Each ethosuximide capsule contains 250 mg ethosuximide, USP. Also contains: polyethylene glycol 400, NF. The capsule contains FD&C yellow No. 6; FD&C red No. 3; gelatin, NF; glycerin, USP; and sorbitol. CLINICAL PHARMACOLOGY Ethosuximide suppresses the paroxysmal three cycle per second spike and wave activity associated with lapses of consciousness which is common in absence (petit mal) seizures. The frequency of epileptiform attacks is reduced, apparently by depression of the motor cortex and elevation of the threshold of the central nervous system to convulsive stimuli. INDICATIONS AND USAGE Ethosuximide is indicated for the control of absence (petit mal) epilepsy. CONTRAINDICATION Ethosuximide should not be used in patients with a history of hypersensitivity to succinimides. WARNINGS BLOOD DYSCRASIAS Blood dyscrasias, including some with fatal outcome, have been reported to be associated with the use of ethosuximide; therefore, periodic blood counts should be performed. Should signs and/or symptoms of infection (e.g., sore throat, fever) develop, blood counts should be considered at that point. EFFECTS ON LIVER AND KIDNEYS Ethosuximide is capable of producing morphological and functional changes in the animal liver. In humans, abnormal liver and renal function studies have been reported. Ethosuximide should be administered with extreme caution to patients with known liver or renal disease. Periodic urinalysis and liver function studies are advised for all patients receiving the drug. SYSTEMIC LUPUS ERYTHEMATOSUS Cases of systemic lupus erythematosus have been reported with the use of ethosuximide. The physician should be alert to this possibility. SUICIDAL BEHAVIOR AND IDEATION Antiepileptic drugs (AEDs), including ethosuximide, increase the risk of suicid Perskaitykite visą dokumentą