Šalis: Kipras
kalba: graikų
Šaltinis: Φαρμακευτικών Υπηρεσιών του Υπουργείου Υγείας
ALVEOLAR SURFACE PHOSPHOLIPIDS (PIG)
CHIESI HELLAS A.E.B.E. (0000010963) GEROULANOU SQ. & 1 RENOU POGGI STR., ALIMOS, 17455
R07AA02
NATURAL PHOSPHOLIPIDS
80MG/ML
SUSPENSION FOR INJECTION
ALVEOLAR SURFACE PHOSPHOLIPIDS (PIG) (8000001348) 120MG
ENDOTRACHEOPULMONARY USE
Εθνική Διαδικασία
NATURAL PHOSPHOLIPIDS
Νομικό καθεστώς: Με Ιατρική Συνταγή; PACK WITH 1 VIAL X 1.5ML (930009301) 1 VIAL - Εγκεκριμένο - Με Ιατρική Συνταγή; PACK WITH 1 VIAL X 3ML (930009303) 1 VIAL - Εγκεκριμένο - Με Ιατρική Συνταγή
PATIENT INFORMATION LEAFLET CUROSURF Curosurf is a natural surfactant prepared from the alveolar surface of porcine lungs, mainly containing phospholipids, especially phosphatidylcholine (70% approx. of the total phospholipid content) and 1-2% approximately of surfactant specific hydrophobic low molecular weight proteins SP-B and SP-C. Lung surfactant is a mixture of substances, chiefly phospholipids and specific proteins, that coats the internal surface of lung alveoli lowering the surface tension. This action is essential to stabilise alveoli, avoiding collapse at end-expiration so that adequate gas exchange is maintained throughout the ventilatory cycle. Deficiency of lung surfactant, from whatever cause, leads to severe respiratory failure named Respiratory Distress Syndrome (RDS) or Hyaline Membrane Disease (HMD). In premature babies, RDS is the major cause of mortality and morbidity in the first days of life being also responsible for long-term respiratory and neurologic sequelae. Curosurf has been developed to replace the deficiency of endogenous pulmonary surfactant by administration of exogenous surfactant into the lower airways. The tensioactive properties of Curosurf favour its uniform distribution into the lungs and spreading at the air-liquid interface in the alveoli. Both physiological and therapeutical effects of Curosurf in surfactant deficiency have been extensively documented in various animal patterns. In premature rabbit foetuses obtained by hysterectomy and immediately sacrificed, the administration of Curosurf caused a marked improvement in lung expansion. In premature rabbit ventilated with 100% O 2 there was a dramatic improvement of tidal volume of about 10ml/kg, treatment with Curosurf increased the compliance of the lung-thorax system up to level similar to that of mature newborn animals. Large international clinical trials have documented the therapeutical effects of Curosurf in babies with RDS. Preterm newborn infants treated with a single dose of Curosurf (2.5ml/kg equal to 200mg/kg Perskaitykite visą dokumentą