ATROPINE SULFATE- atropine sulfate injection

Šalis: Jungtinės Valstijos

kalba: anglų

Šaltinis: NLM (National Library of Medicine)

Veiklioji medžiaga:

ATROPINE SULFATE (UNII: 03J5ZE7KA5) (ATROPINE - UNII:7C0697DR9I)

Prieinama:

A-S Medication Solutions

Vartojimo būdas:

PARENTERAL

Recepto tipas:

PRESCRIPTION DRUG

Terapinės indikacijos:

Atropine Sulfate Injection, USP, may be given parenterally as a pre-anesthetic medication in surgical patients to reduce salivation and bronchial secretions. It may also be used to suppress vagal activity associated with the use of halogenated hydrocarbons during inhalation anesthesia and reflex excitation arising from mechanical stimulation during surgery. The antispasmodic action of atropine is useful in pylorospasm and other spastic conditions of the gastrointestinal tract. For ureteral and biliary colic, atropine concomitantly with morphine may be indicated. Atropine relaxes the upper GI tract and colon during hypotonic radiography. In poisoning by the organic phosphate cholinesterase inhibitors found in certain insecticides and by chemical warfare nerve gases, large doses of atropine relieve the muscarine-like symptoms and some of the central nervous system manifestations. It is also used as an antidote for mushroom poisoning due to muscarine in certain species such as Amanita muscaria . Atropine Sulfate

Produkto santrauka:

Product: 50090-3138 NDC: 50090-3138-0 10 mL in a SYRINGE / 10 in a CARTON

Autorizacija statusas:

unapproved drug other

Prekės savybės

ATROPINE SULFATE - ATROPINE SULFATE INJECTION
A-S MEDICATION SOLUTIONS
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this_
_labeling has not been approved by FDA. For further information about
unapproved_
_drugs, click here._
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ATROPINE SULFATE
INJECTION, USP
DESCRIPTION
Atropine is chemically 1 α H, 5 α H - Tropan-3 α-ol (±) -tropate
(ester), with the following
structural formula:
Atropine rarely occurs as such in any of the plants and has been
prepared by synthesis.
It is usually employed in the form of atropine sulfate (the sulfate
[2:1] monohydrate salt
of atropine), which has much greater solubility in water.
Atropine Sulfate Injection, USP, is a sterile aqueous solution of
atropine sulfate. Each mL
contains atropine sulfate, 0.1 mg; sodium chloride, 8.8 mg, for
isotonicity; citric acid,
0.63 mg, and sodium citrate, 0.29 mg, as buffers. May contain
additional citric acid
and/or sodium citrate for pH adjustment (3.0-6.5). The air above the
liquid in the
container has been displaced by nitrogen gas.
CLLNICAL PHARMACOLOGY
Atropine inhibits the muscarinic actions of acetylcholine at
postganglionic
parasympathetic neuroeffector sites including smooth muscle, secretory
glands and
CNS sites. Large doses may block nicotinic receptors at the autonomic
ganglia and at
the neuromuscular junction.
Specific anticholinergic responses are dose-related. Small doses of
atropine inhibit
salivary and bronchial secretions and sweating; moderate doses dilate
the pupil, inhibit
accommodation and increase the heart rate (vagolytic effect); larger
doses will decrease
motility of the GI and urinary tracts; very large doses will inhibit
gastric acid secretion.
INDICATIONS AND USAGE
Atropine Sulfate Injection, USP, may be given parenterally as a
pre-anesthetic medication
in surgical patients to reduce salivation and bronchial secretions. It
may also be used to
suppress vagal activity associated with the use of halogenated
hydrocarbons during
inhalation anesthesia and reflex excitation arisi