ATENOLOL tablet

Šalis: Jungtinės Valstijos

kalba: anglų

Šaltinis: NLM (National Library of Medicine)

Veiklioji medžiaga:

ATENOLOL (UNII: 50VV3VW0TI) (ATENOLOL - UNII:50VV3VW0TI)

Prieinama:

St Marys Medical Park Pharmacy

INN (Tarptautinis Pavadinimas):

ATENOLOL

Sudėtis:

ATENOLOL 100 mg

Recepto tipas:

PRESCRIPTION DRUG

Autorizacija statusas:

Abbreviated New Drug Application

Prekės savybės

ATENOLOL- ATENOLOL TABLET
ST MARYS MEDICAL PARK PHARMACY
----------
ATENOLOL TABLETS, USP
RX ONLY
DESCRIPTION
Atenolol, a synthetic, beta
-selective (cardioselective) adrenoreceptor blocking agent, may be
chemically described as benzeneacetamide, 4 -[2’-hydroxy-3’-[(1-
methylethyl) amino] propoxy]-. The
molecular formula is C
H
N
O
and its structural formula is:
Atenolol (free base) has a molecular weight of 266. It is a relatively
polar hydrophilic compound with a
water solubility of 26.5 mg/mL at 37° C and a log partition
coefficient (octanol/water) of 0.23. It is
freely soluble in 1N HCl (300 mg/mL at 25° C) and less soluble in
chloroform (3 mg/mL at 25° C).
Atenolol tablets, USP are available as 25, 50 and 100 mg tablets for
oral administration.
Inactive Ingredients: Colloidal silicon dioxide, corn starch,
magnesium carbonate, magnesium stearate,
sodium lauryl sulfate, sodium starch glycolate.
CLINICAL PHARMACOLOGY
Atenolol is a beta
-selective (cardioselective) beta-adrenergic receptor blocking agent
without
membrane stabilizing or intrinsic sympathomimetic (partial agonist)
activities. This preferential effect is
not absolute, however, and at higher doses, atenolol inhibits beta
-adrenoreceptors, chiefly located in
the bronchial and vascular musculature.
PHARMACOKINETICS AND METABOLISM
In man, absorption of an oral dose is rapid and consistent but
incomplete. Approximately 50% of an oral
dose is absorbed from the gastrointestinal tract, the remainder being
excreted unchanged in the feces.
Peak blood levels are reached between two (2) and four (4) hours after
ingestion. Unlike propranolol or
metoprolol, but like nadolol, atenolol undergoes little or no
metabolism by the liver, and the absorbed
portion is eliminated primarily by renal excretion. Over 85% of an
intravenous dose is excreted in urine
within 24 hours compared with approximately 50% for an oral dose.
Atenolol also differs from
1
14
22
2
3
1
2
propranolol in that only a small amount (6% to 16%) is bound to
proteins in the plasma. This kineti