Šalis: Malaizija
kalba: anglų
Šaltinis: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
METOPROLOL TARTRATE
PHARMAFORTE (MALAYSIA) SDN. BHD.
METOPROLOL TARTRATE
30Tablet Tablets; 500Tablet Tablets; 1000Tablet Tablets; 500 Tablet Tablets
APOTEX INC
PHARMACOLOGY: APO-METOPROLOL (metoprolol tartrate) is a beta- adrenergic blocking agent with predominant blocking effect on beta1- receptors. Although the mechanism of the antihypertensive effect has not been established with certainty, the following factors may be involved: a) competitive ability to antagonize catecholamine-induced tachycardia at the beta-receptor sites in the heart, thus decreasing cardiac output, b) inhibition of renin release by the kidney, c) inhibition of the vasomotor centres. The mechanism of the anti-anginal effect is also uncertain. An important factor may be the reduction of myocardial oxygen requirements by blocking catecholamine-induced increases in heart rate, systolic pressure, and the velocity and extent of myocardial contraction. In man, metoprolol is rapidly and nearly completely absorbed from the gastrointestinal tract. Due to the large hepatic first pass elimination, only half of the dose reaches the systemic circulation. This fraction increases to 70-80% with prolonged therapy. Metoprolol is extensively distributed to extravascular tissues. The maximum plasma concentrations are reached within 1 1 / 2 - 2 hours. Binding to serum protein is about 10%. The plasma half-life is approximately 3 hours. The elimination rate is not dose-dependent in the therapeutic range. In humans, metoprolol is metabolized into three main urinary metabolites. Two of these have some pharmacological activity which do not contribute significantly to the beta-blocking effect of the parent compound. More than 90% of an oral therapeutic dose is recovered in the urine within 72 hours. Metoprolol is excreted mainly by glomerular filtration. INDICATIONS: Hypertension: In the treatment of patients with mild or moderate hypertension. It is usually used in combination with other drugs, particularly a thiazide diuretic. However, it may be tried alone as an initial agent in those patients in whom, in the judgment of the physician, treatment should be started with a beta-blocker rather than a diuretic. The combina Perskaitykite visą dokumentą