Šalis: Jungtinės Valstijos
kalba: anglų
Šaltinis: NLM (National Library of Medicine)
AMINOPHYLLINE DIHYDRATE (UNII: C229N9DX94) (AMINOPHYLLINE - UNII:27Y3KJK423)
West-ward Pharmaceutical Corp
AMINOPHYLLINE DIHYDRATE
AMINOPHYLLINE DIHYDRATE 100 mg
PRESCRIPTION DRUG
Abbreviated New Drug Application
AMINOPHYLLINE- AMINOPHYLLINE DIHYDRATE TABLET WEST-WARD PHARMACEUTICAL CORP ---------- AMINOPHYLLINE TABLETS, USP REV. 12/02RX ONLY DESCRIPTION Aminophylline is a 2:1 complex of theophylline and ethylenediamine. Theophylline is structurally classified as a methyxanthine. Aminophylline occurs as a white or slightly yellowish granule or powder, with a slight ammoniacal odor. Aminophylline has the chemical name 1_H_-Purine-2,6-dione,3,7- dihydro-1,3-dimethyl-,compound with 1,2 ethanedamine (2:1) and is represented by the following structural formula: The molecular formula of aminophylline dihydrate is C H N O •(H O) with a molecular weight of 456.46. Aminophylline is available as tablets intended for oral administration, containing 100 mg or 200 mg of Aminophylline, USP (calculated as the dihydrate) per tablet (equivalent to 79 mg or 158 mg of theophylline anhydrous). Inactive ingredients: Magnesium Stearate and Microcrystalline Cellulose. CLINICAL PHARMACOLOGY MECHANISM OF ACTION: Theophylline has two distinct actions in the airways of patients with reversible obstruction; smooth muscle relaxation (i.e., bronchodilation) and suppression of the response of the airways to stimuli (i.e., non-bronchodilator prophylactic effects). While the mechanisms of action of theophylline are not known with certainty, studies in animals suggest that bronchodilatation is mediated by the inhibition of two isozymes of phosphodiesterase (PDE III and, to a lesser extent, PDE IV) while non-bronchodilator prophylactic actions are probably mediated through one or more different molecular mechanisms, that do not involve inhibition of PDE III or antagonism of adenosine receptors. Some of the adverse effects associated with theophylline appear to be mediated by inhibition of PDE III (e.g., hypotension, tachycardia, headache, and emesis) and adenosine receptor antagonism (e.g., alterations in cerebral blood flow). Theophylline increases the force of contraction of diaphragmatic muscles. This action appears to be due to enhancement of calcium Perskaitykite visą dokumentą