TRIAMCINOLONE ACETONIDE ointment

국가: 미국

언어: 영어

출처: NLM (National Library of Medicine)

유효 성분:

TRIAMCINOLONE ACETONIDE (UNII: F446C597KA) (TRIAMCINOLONE ACETONIDE - UNII:F446C597KA)

제공처:

Carolina Medical Products Company

INN (국제 이름):

TRIAMCINOLONE ACETONIDE

구성:

TRIAMCINOLONE ACETONIDE 0.5 mg in 1 g

처방전 유형:

PRESCRIPTION DRUG

승인 상태:

Abbreviated New Drug Application

제품 특성 요약

TRIAMCINOLONE ACETONIDE- TRIAMCINOLONE ACETONIDE OINTMENT
CAROLINA MEDICAL PRODUCTS COMPANY
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TRIAMCINOLONE ACETONIDE 0.05% IN ABSORBASE
DESCRIPTION
Topical corticosteroids, such as triamcinolone acetonide, constitute a
class of primarily synthetic
steroids used as anti-inflammatory and antipruritic agents.
Each gram of Triamcinolone Acetonide 0.05% in Absorbase
(Triamcinolone Acetonide Ointment
USP) contains 0.5 mg of Triamcinolone Acetonide USP in a water-in-oil
emulsion composed of Light
Mineral Oil NF, Purified Water USP, White Petrolatum USP, Heavy
Mineral Oil USP, Mineral Wax,
and Lanolin Alcohols NF. The white ointment is for topical use only.
Triamcinolone Acetonide has the molecular formula of C
H FO and is designated chemically as
Pregna-1,4-diene-3, 20-dione, 9-fluoro-11, 21-dihydroxy-16,
17-[(1-methylethylidene)bis(oxy)]-, (11β,
16α)-. It has a molecular weight of 434.50 and the following
structural formula:
CLINICAL PHARMACOLOGY
Topical corticosteroids share anti-inflammatory, antipruritic and
vasoconstrictive actions.
The mechanism of anti-inflammatory activity of the topical
corticosteroids is unclear. Various
laboratory methods, including vasoconstrictor assays, are used to
compare and predict potencies and/or
clinical efficacies of the topical corticosteroids. There is some
evidence to suggest that a
recognizable correlation exists between vasoconstrictor potency and
therapeutic efficacy in man.
PHARMACOKINETICS
The extent of percutaneous absorption of topical corticosteroids is
determined by many factors
including the vehicle, the integrity of the epidermal barrier, and the
use of occlusive dressings.
Topical corticosteroids can be absorbed from normal intact skin.
Inflammation and/or other disease
processes in the skin increase percutaneous absorption. Occlusive
dressings substantially increase the
percutaneous absorption of topical corticosteroids. Thus, occlusive
dressings may be a valuable
therapeutic adjunct for treatment of resistant dermatoses (See DOSAGE
AND ADMINISTRATION).
O