Teveten

국가: 뉴질랜드

언어: 영어

출처: Medsafe (Medicines Safety Authority)

유효 성분:

Eprosartan mesilate 200mg

제공처:

Pharmacy Retailing (NZ) Ltd t/a Healthcare Logistics

INN (국제 이름):

Eprosartan mesilate 200 mg

복용량:

200 mg

약제 형태:

Film coated tablet

구성:

Active: Eprosartan mesilate 200mg Excipient: Croscarmellose sodium Lactose monohydrate Magnesium stearate Microcrystalline cellulose Opadry Pregelatinised maize starch Purified water

패키지 단위:

Blister pack, PVC/PVdC or Aclar/Al,

수업:

Prescription

처방전 유형:

Prescription

Manufactured by:

SmithKline Beecham (Cork) Ltd

제품 요약:

Package - Contents - Shelf Life: Blister pack, PVC/PVdC or Aclar/Al -   - 24 months from date of manufacture stored at or below 25°C - Bottle, plastic, HDPE -   - 24 months from date of manufacture stored at or below 25°C

승인 날짜:

1996-10-23

제품 특성 요약

TEVETEN 
_EPROSARTAN MESYLATE TABLETS 400MG & 600MG _
DESCRIPTION 
Teveten (eprosartan mesylate) is a non-biphenyl nontetrazole
angiotensin II 
receptor (AT
1
) antagonist. It is chemically described as the 
monomethanesulphonate of
(_E_)-α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-
imidazol-5-yl]methylene]-2-thiophenepropanoic acid.  
It has a molecular weight (MW) of 520.6 and may be represented
structurally 
as: 

Eprosartan mesylate (CAS 0144143-96-4) is a white to off-white powder
with 
a melting point range of 248°C to 250°C and at room temperature has
a 
solubility of 0.91 mg/mL in water at a pH of 7. 
Teveten tablets contain eprosartan mesylate equivalent to either 400
mg or 
600 mg eprosartan as the active ingredient. The tablets also contain
lactose, 
cellulose- microcrystalline, starch- pregelatinised maize, magnesium
stearate, 
titanium dioxide, hypromellose , macrogol 400 and polysorbate 80 as 
excipients. Each tablet strength also contains various other
ingredients as 
follows: 
400 mg: croscarmellose sodium, iron oxide yellow (CI 77492) and iron
oxide 
red (CI 77491). 
600 mg: crospovidone. 
PHARMACOLOGY  
Eprosartan is a potent angiotensin II receptor antagonist, which
selectively 
binds to the AT
1
 receptor. Angiotensin II is a potent vasoconstrictor, and the 
primary active hormone of the renin-angiotensin-aldosterone system,
playing 
a major part in the pathophysiology of hypertension. Angiotensin II
binds to 
AT
1
 receptors in many tissues (e.g. smooth vascular musculature,
kidney 
suprarenals and heart) and produces biological effects such as 
vasoconstriction, sodium retention and release of aldosterone. 
Eprosartan blocks the binding of angiotensin II to the AT
1
 receptors, which 
prevents vasoconstriction, thus lowering blood pressure and
aldosterone 
secretion. In hypertensive patients, comparable blood pressure control
is 
achieved when eprosartan is administered once or twice daily. Blood
pressure 
control is maintained in a consisten