TALACEN pentazocine hydrochloride and acetaminophen tablet

국가: 미국

언어: 영어

출처: NLM (National Library of Medicine)

유효 성분:

pentazocine hydrochloride (UNII: A36BXO4PPX) (pentazocine - UNII:RP4A60D26L)

제공처:

sanofi-aventis U.S. LLC

INN (International Name):

pentazocine hydrochloride

구성:

25 mg

처방전 유형:

PRESCRIPTION DRUG

제품 특성 요약

TALACEN- PENTAZOCINE HYDROCHLORIDE AND ACETAMINOPHEN TABLET
SANOFI-AVENTIS U.S. LLC
----------
TALACEN
PENTAZOCINE HYDROCHLORIDE, USP,
AND ACETAMINOPHEN, USP.
CIV
DESCRIPTION
TALACEN is a combination of pentazocine hydrochloride, USP, equivalent
to 25 mg base and
acetaminophen, USP, 650 mg.
Pentazocine is a member of the benzazocine series (also known as the
benzomorphan series).
Chemically, pentazocine is (2R*, 6R*,
11R*)1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-
butenyl)-2,6-methano-3-benzazocin-8-ol, a white, crystalline substance
soluble in acidic aqueous
solutions, and has the following structural formula:
Chemically, acetaminophen is Acetamide, _N_-(4-hydroxyphenyl)-, and
has the following structural
formula:
Pentazocine is an analgesic and acetaminophen is an analgesic and
antipyretic.
_Inactive Ingredients_: Colloidal Silicon Dioxide, FD&C Blue #1,
Gelatin, Microcrystalline Cellulose,
Potassium Sorbate, Pregelatinized Starch, Sodium Lauryl Sulfate,
Sodium Metabisulfite, Sodium Starch
Glycolate, Stearic Acid.
CLINICAL PHARMACOLOGY
TALACEN is an analgesic possessing antipyretic actions.
Pentazocine is an analgesic with agonist/antagonist action which when
administered orally is
approximately equivalent on a mg for mg basis in analgesic effect to
codeine.
Acetaminophen is an analgesic and antipyretic.
®
Onset of significant analgesia with pentazocine usually occurs between
15 and 30 minutes after oral
administration, and duration of action is usually three hours or
longer. Onset and duration of action and
the degree of pain relief are related both to dose and the severity of
pretreatment pain. Pentazocine
weakly antagonizes the analgesic effects of morphine, meperidine, and
phenazocine; in addition, it
produces incomplete reversal of cardiovascular, respiratory, and
behavioral depression induced by
morphine and meperidine. Pentazocine has about 1/50 the antagonistic
activity of nalorphine. It also has
sedative activity.
Pentazocine is well absorbed from the gastrointestinal tract. Plasma
levels clos