LACTULOSE SOLUTION

국가: 캐나다

언어: 영어

출처: Health Canada

유효 성분:

LACTULOSE

제공처:

SANIS HEALTH INC

ATC 코드:

A06AD11

INN (국제 이름):

LACTULOSE

복용량:

667MG

약제 형태:

SOLUTION

구성:

LACTULOSE 667MG

관리 경로:

ORAL

패키지 단위:

15G/50G

처방전 유형:

OTC

치료 영역:

AMMONIA DETOXICANTS

제품 요약:

Active ingredient group (AIG) number: 0113020001; AHFS:

승인 상태:

APPROVED

승인 날짜:

2022-08-18

제품 특성 요약

PRESCRIBING INFORMATION
LACTULOSE
LACTULOSE SOLUTION, USP
667 MG/ML
COLONIC CONTENT ACIDIFIER - LAXATIVE
SANIS HEALTH INC.
333 Champlain Street, Suite 102
Dieppe, New Brunswick
E1A 1P2
www.sanis.com
DATE OF REVISION:
July 24, 2015
CONTROL NO.: 186111
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_LACTULOSE Prescribing Information _
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PRESCRIBING INFORMATION
LACTULOSE
LACTULOSE SOLUTION, USP
667 MG/ML
THERAPEUTIC CLASSIFICATION
Colonic Content Acidifier - Laxative
ACTION AND CLINICAL PHARMACOLOGY
LACTULOSE (lactulose solution), a disaccharide sugar containing one
molecule of galactose and
one molecule of fructose, is a synthetic derivative of lactose.
LACTULOSE is a solution in water
prepared from Lactulose concentrate. It contains lactulose, galactose,
lactose, fructose and
epilactose.
In patients with portal-systemic encephalopathy (PSE), lactulose
solution causes a decrease in
blood ammonia concentration and reduces the degree of PSE. Although
the mechanism of action
of lactulose solution has not been clearly defined, it appears to be
associated primarily with the
metabolism of the sugar in the lower intestinal tract. The breakdown
of lactulose solution to
organic acids (i.e., lactic acid and small amounts of formic and
acetic acids) by the saccharolytic
bacteria in the colon acidifies the contents of the colon. In patients
with PSE who respond to
lactulose solution, a decrease in fecal pH occurs. Acidification of
colon contents inhibits the
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_LACTULOSE Prescribing Information _
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nonionic diffusion of ammonia from the colon into the blood. In
addition, since the contents of the
colon are more acidic than is blood, ammonia (NH
3
) can diffuse from the blood into the colon. In
the acidic colon, ammonia is converted to ammonium ions (NH4
+
) thereby preventing its
absorption. In a similar manner, the absorption of amines (which may
also contribute to the
development of PSE) may also be reduced.
Finally the cathartic action of lactulose solution (which is probably
caused by the osmotic effect of
the organic acid metabolites of