국가: 남아프리카
언어: 영어
출처: South African Health Products Regulatory Authority (SAHPRA)
Knoll
ISOPTIN® 40 mg Film Coated Tablets SCHEDULING STATUS: S3 PROPRIETARY NAME (and dosage form): ISOPTIN ® 40 mg Film Coated Tablets COMPOSITION: Each film coated tablet contains 40 mg verapamil hydrochloride. PHARMACOLOGICAL CLASSIFICATION: A 7.1.4 Vasodilators - Coronary and other medicines used in Angina pectoris PHARMACOLOGICAL ACTION: The calcium antagonist verapamil reduces myocardial oxygen consumption in vitro directly by intervening in the energy consuming metabolic processes of the myocardial cell, and indirectly by diminishing the peripheral resistance (after- load). It prolongs impulse conduction in the AV node. INDICATIONS: Angina pectoris (acute and chronic coronary insufficiency), supraventricular tachydysrhythmia. CONTRA-INDICATIONS: Retarded AV conduction (second and third degree AV block), acute stage of myocardial infarction, sick-sinus syndrome. DOSAGE AND DIRECTIONS FOR USE: The doses of Isoptin as prescribed by the physician are to be taken regularly, preferably half an hour before meals together with some liquid. The average daily dose is 120 mg - 360 mg in three divided doses where possible. SIDE EFFECTS AND SPECIAL PRECAUTIONS: As Isoptin inhibits AV conduction, it may cause AV block. Isoptin may also lead to a transient decrease in blood pressure, even in normotensive patients. Constipation, headache, fatigue, palpitations, first and second degree AV block, SA block, epigastric pain, flush, dizziness, urticaria and temporary skin rash may occur. Reversible increase of transaminases and/or alkaline phosphatase has been observed and is most probably a response to allergic hepatitis. Reports of individuals experiencing exacerbation of arthritis, increased urination, burning sensations of the gums, mild tremor and severe facial pain are known. Where heart failure is p 전체 문서 읽기