국가: 말레이시아
언어: 영어
출처: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
GLIPIZIDE
IMEKS PHARMA SDN. BHD.
GLIPIZIDE
100 Tablets; 500 Tablets
Sriprasit Pharma Co. Ltd.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ GIPZIDE TABLET Glipizide (5mg) _ _ 1 WHAT IS IN THIS LEAFLET 1. What GIPZIDE is used for 2. How GIPZIDE works 3. Before you use GIPZIDE 4. How to use GIPZIDE 5. While you are using it 6. Side effects 7. Storage and Disposal of GIPZIDE 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT GIPZIDE IS USED FOR GIPZIDE is used in addition to diet and exercise to control blood sugar level in people with type 2 diabetes mellitus. HOW GIPZIDE WORKS GIPZIDE belongs to a group of medicines called sulphonylureas, containing the active ingredient glipizide. GIPZIDE helps to lower blood sugar level by stimulating the release of insulin from your pancreas. BEFORE YOU USE GIPZIDE_ _ - _When you must not use it_ Do not take GIPZIDE if you have/are: • allergic to glipizide, other sulphonylureas or sulphonamides, or any other ingredients of this medicine (listed in Product Description). • insulin-dependent (type 1) diabetes mellitus. • diabetes ketoacidosis with or without loss of consciousness. • severe problems with your kidneys or liver. • taking miconazole (antifungal medication). _ _ _Pregnancy and lactation _ Please consult your doctor or pharmacist if you are pregnant, planning for pregnancy or breastfeeding before using any medicine. Do not take GIPZIDE if you are pregnant, as it may potentially cause harm to your baby. If you could get pregnant while receiving GIPZIDE, a reliable form of contraception should always be used. It is unknown whether GIPZIDE secreted into the breast milk or not, however, due to the risk of side effects in the baby, breastfeeding is not recommended while taking GIPZIDE. _ _ _ _ - _Before you start to use it _ Please consult your doctor or pharmacist if you have/are: • glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency (disorder that may cause abnormal destruction of red blood cells). • kidney or liver impairment. • high risk of getting low blood sugar (elderly, weak body or not 전체 문서 읽기
CONTENT Each tablet contains Glipizide 5 mg. DESCRIPTION White round tablet with a bisect and embossed with “SPS”, “G06” on one side, plain on the other. PHARMACODYNAMICS Glipizide is an oral blood-glucose lowering agent of the second-generation sulphonylureas group. When administered orally, glipizide stimulates insulin secretion from the beta cells of pancreatic islet tissue. As such, its action is dependent on the functioning of the beta cells in pancreatic islet tissue, which produce endogenous insulin. Stimulation of insulin secretion by glipizide is most pronounced in response to a meal. Long-term administration of glipizide does not affect the fasting insulin level, however, it enhances the postprandial insulin response following 6 months of treatment. The insulinotropic response to a meal occurs within 30 minutes after an oral dose of Gipzide in diabetic patients, but elevated insulin levels do not persist beyond the time of the meal challenge. Blood sugar control persists in some patients for up to 24 hours after a single dose of Gipzide, even though plasma levels have declined to a small fraction of peak levels by that time. PHARMACOKINETICS Glipizide is rapidly and completely absorbed after oral administration. Peak plasma concentration occurs 1 – 3 hours after a single oral dose. The elimination half-life for both oral administration and intravenous administration ranges from 2 – 4 hours in healthy subjects. First-pass metabolism effect for glipizide is not significant. When administered with meals, the absorption of glipizide is delayed by about 40 minutes, however, the total absorption and disposition of an oral dose is not affected. Glipizide is 98 – 99% bound to plasma protein, one hour after oral or intravenous administration. Metabolism of glipizide occurs mainly in the liver. The primary metabolites which are the inactive hydroxylation products and the polar conjugates are excreted mainly in the urine and less than 10% of glipizide is excreted unchanged. INDICATIONS Glipizide is i 전체 문서 읽기